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SUMMARY:IMX Seminar Series - Leveraging Soft Matter Concepts for Advanced 
 Manufacturing of Pharmaceutical Drug Products
DTSTART:20211025T131500
DTEND:20211025T141500
DTSTAMP:20260415T191334Z
UID:e0705c64ddeaeca405e78031afe56eb716ae0cdbf9ee6917bdbc82b3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Patrick Doyle\, MIT\, USA\nAdvances in modern drug manuf
 acturing have primarily focused on discovery and synthesis of the active p
 harmaceutical ingredient (API). However processes to turn this API into th
 e final drug product are multi-step batch processes\, energy intensive\, i
 nflexible and wasteful. For example\, large millimetric crystals are first
  formed which are then ground down to sub-micron sizes through energy inte
 nsive\, tedious processes which can damage the API. These small crystals a
 re then blended with a variety of binding and stabilizing materials in a t
 rial and error fashion. Independent control over the drug loading\, crysta
 l properties\, and release profile are not possible. In this talk I will d
 iscuss technologies being developed in our group which leverage soft matte
 r materials and flow physics for advanced pharmaceutical manufacturing.  
 I will first review  microhydrogel and nanoemulsion systems which allow u
 s to perform in situ API crystallization within template microcarriers. Wi
 th this process we can independently control API crystal size\, loading an
 d release profiles.  Next\, I will review a recent technique we have deve
 loped called embedded droplet printing. This process leverages yield stres
 s fluids and allows us to process droplets in an “absolutely quiescent s
 tate”.  The platform is used for the rapid production of pharmaceutical
  particles that are highly spherical and uniform\, key targets for flowabi
 lity\, and ultimately manufacturability of pharmaceutical drug products.\n
  
LOCATION:https://epfl.zoom.us/j/63529996287
STATUS:CONFIRMED
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