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SUMMARY:Synaptic transmission: from mechanisms of transmitter release to s
 ynapse specificity
DTSTART:20110922T121500
DTSTAMP:20260502T085625Z
UID:aad5a1980beb0b0d3767117d3f42f5b50b5b9e3bdfc00ed25e6c0e65
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Ralf Schneggenburger\nSynaptic transmission is the basis fo
 r information flow in neuronal circuits\, and is initiated by vesicle fusi
 on and transmitter release at the presynaptic active zone. Dysfunction of 
 synapses and synaptic circuits is also often an underlying cause for neuro
 psychiatric - and neurodegenerative disorders. Our lab investigates fundam
 ental synaptic signaling mechanisms using an experimentally accessible syn
 apse in the auditory system\, the calyx of Held. In recent years\, we have
  established and successfully used in-vivo protein overexpression and Cre-
 lox mediated conditional gene removal at the calyx of Held. These approach
 es have revealed new roles for the Ca2+ sensor protein Synaptotagmin-2 (1)
 \, and for the active zone protein RIM in the control of transmitter relea
 se at the active zone (2). Beyond signaling at individual active zones\, s
 ynaptic strength will depend on the number of active zones contained in a 
 synaptic connection\, and therefore\, on synapse size. Recent evidence fro
 m our lab identifies a role for bone morphogenetic protein (BMP) signaling
  in determining synapse size and synaptic connectivity patterns during the
  development of auditory circuits. These studies enhance our understanding
  of the molecular physiology of transmitter release in the brain\, and of 
 signaling mechanisms that help establishing specific synaptic connectivity
  in neuronal circuits.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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