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SUMMARY:Biomechanics\, Biomaterial\, and Clinical Application: The Good\, 
 the Bad and the Ugly
DTSTART:20210917T123000
DTEND:20210917T133000
DTSTAMP:20260928T184406Z
UID:9a1460a73758510edcf370cc2b47800bb4f93c72dfaae34a4bf8b330
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dominique Pioletti\, Institute of Bioengineering\, Schoo
 l of Engineering\, EPFL\, Lausanne (CH)\nBIOENGINEERING SEMINAR\n\nAbstrac
 t:\nFrom a recent report of the WHO\, approximately 1.71 billion people ha
 ve musculoskeletal conditions worldwide. These disorders not only affect t
 he quality of life of affected people but in certain cases can be a life-t
 hreatening situation. Disorders include osteoarthritis\, osteoporosis\, fr
 agility or traumatic fractures as well ruptures of soft tissues to mention
  a few. A common trend between most of the musculoskeletal conditions is a
  mismatch between the biomechanical properties of the concerned tissues an
 d their mechanical environment. Biomechanical analyses are therefore essen
 tial to describe the pathophysiological situation arising in musculoskelet
 al tissues. These analyses allow us to determine mechanical targets for th
 e development of biomaterials intended to replace damaged tissues. In this
  talk\, I will present the development of a hydrogel family with controlla
 ble mechanical and adhesive properties. The tunability of the hydrogels ar
 e based on particular considerations of dissipative phenomena arising duri
 ng their deformation. The obtained hydrogels are used to target different 
 clinical applications. We will therefore be in a position to determine bet
 ween biomechanics\, biomaterials and clinical applications which one is th
 e good\, the bad and the ugly.\n\nBio:\nAfter undergraduate studies in Phy
 sics at EPFL\, Dominique Pioletti pursued his education in the same instit
 ution and obtained his PhD in biomechanics in 1997. He developed original 
 constitutive laws for soft tissues taking into account viscoelasticity in 
 large deformation situations. Then he spent two years at UCSD (California\
 , USA) as a post-doc fellow and was interested in particular to understand
  the molecular and cellular mechanisms leading to peri-implant osteolysis.
  He developed at that time the pioneer idea to use orthopedic implants as 
 drug delivery systems and has since proposed different solutions relevant 
 for clinical applications. Since his return to the EPFL\, he has combined 
 biomechanical\, biological and materials science aspects to develop new so
 lutions for clinical problems related to the musculoskeletal system. In pa
 rticular\, he has co-founded a start-up company (flowbone.com) to translat
 e the development of an injectable hydrogel used to prevent osteoporotic f
 racture. His research topics include biomechanics of the musculoskeletal s
 ystem\, mechanobiology in bone and cartilage\, drug delivery systems for b
 one and cartilage\, and functional tissue engineering. His close collabora
 tion with different hospital departments has resulted in research output o
 riented toward applications.\n\nZoom link for attending remotely: https://
 epfl.zoom.us/j/65880406577\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/65880406577
STATUS:CONFIRMED
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