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SUMMARY:EPFL BioE Talks SERIES  "Engineered Immune Cell Therapies for Mali
 gnant Glioma"
DTSTART:20211004T160000
DTEND:20211004T170000
DTSTAMP:20260510T025806Z
UID:c2499f0499209b4858770bb7b51260057995fc1aebac2e451080bf78
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Denis Migliorini\, Department of Oncology\, University o
 f Geneva (CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nTumors arising 
 in the brain are notoriously hard to treat. Intensive research in the last
  decade provided in depth characterization of the molecular profile of hig
 h grade gliomas\, but unfortunately no impactful novel therapies. We cont
 ributed to immune based therapies for gliomas\, especially in the identifi
 cation of overexpressed cell surface markers of GBM in vivo and with the d
 evelopment multiepitopic vaccinations using synthetic peptides. We had the
  opportunity to translate our research into the clinic in an early phase t
 rial where 19 patients with newly diagnosed GBM tumors were treated with t
 he IMA950 peptide vaccine. The approach was safe and immunogenic. Our lab
 ’s expertise is to develop improved chimeric antigen receptor (CAR)-T c
 ell approaches for solid tumors with a focus on glioma for the development
  of translational programs. At the EPFL BioE Talks I will give an overview
  of our CAR pipeline with the various approaches we are using (Multivalent
  RNA electroporated CARs\, combination of CAR-T with modified oncolytic vi
 ruses\, among others).\n\nBio:\nJan 2020- Present\nGroup leader of the Bra
 in Tumor and Immune Cell Engineering (BTICE) Lab. at AGORA Lausanne\nAtte
 nding physician in charge of the Brain tumor clinic at University of Genev
 a Hospital (HUG)\nJan 2020 Assistant Professor\, Department of Oncology\, 
 University of Geneva\n2017-2019 Postdoctoral Research Fellowship\, Center 
 for Cellular Immunotherapies\, University of Pennsylvania\, PA (Advisors: 
 Carl H. June\, Avery D. Posey)\n2014- 2016 Clinical Fellowship Neuro oncol
 ogy\, Department of Oncology\, University Hospital of Geneva (Advisor: Pie
 rre-Yves Dietrich)\n2011-2014 Post graduate training Medical Oncology\, Un
 iversity Hospital of Geneva\n2008-2011 Post graduate training Internal Med
 icine\, University Hospital of Strasbourg\n2002-2008 M.D. University of To
 ulouse Medical School.\n\n\nIMPORTANT NOTICE:\nAs a consequence of the ong
 oing Covid-19 pandemic\, in-person attendance of this seminar is subjected
  to some constraints:\n\n	Maximum number of participants is limited to 80 
 (2/3 of room SV1717's nominal capacity): first come\, first served!\n	Vali
 d COVID certificate and ID are required to enter the meeting room\n	Face m
 asks are mandatory for everyone in the seminar room (excepted the speaker 
 while presenting).\n\nThank you warmly for your understanding!\n\nAlternat
 ively\, the seminar can also be followed via Zoom web-streaming:\nZoom lin
 k (with one-time registration for the whole series) for attending remotely
 : https://go.epfl.ch/EPFLBioETalks
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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