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SUMMARY:EPFL BioE Talks SERIES  "Principles of Protein Assembly in Cells"
DTSTART:20211011T160000
DTEND:20211011T170000
DTSTAMP:20260428T051608Z
UID:9c5b89a907973dffee5bb4894b6e41f597c92348d5b5a84c62b1499d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Emmanuel Levy\, Department of Chemical and Structural Bi
 ology\, Weizmann Institute of Science\, Rehovot (IL)\nWEEKLY EPFL BIOE TAL
 KS SERIES\n\nAbstract:\nLife processes involve an intricate choreography b
 etween tens of millions of protein building blocks that form the infrastru
 cture of cells. Recent technological advances have revealed the catalogs o
 f proteins present in various cells and organisms. However\, understanding
  how these protein building-blocks assemble and work together is an extrao
 rdinarily complex task. I will present our work aimed at addressing this c
 hallenge. First\, I will describe how stickiness\, defined as the chemical
  propensity of protein surfaces to bind to each other\, is tuned across en
 tire proteomes to minimize promiscuous interactions. Second\, I will show 
 that even single point-mutations changing the surface stickiness of homo-o
 ligomeric proteins can trigger their infinite folded-state self-assembly. 
 Finally\, I will describe the design of synthetic protein condensates with
  tractable and tunable phase behavior\; and work-in-progress\, on how we a
 re using these condensates to identify genes globally regulating macromole
 cular self-assembly in cells.\n\nBio:\nEmmanuel Levy is a biologist integr
 ating computational and experimental work to solve nature’s riddles. His
  research concentrates on the principles of protein assembly. His notable 
 contributions include the determination of physiologically relevant assemb
 ly states for proteins of known structure\, the discovery of protein surfa
 ce hot-spots\, where mutations readily trigger new assemblages\, and the c
 haracterization of negative design principles safeguarding proteins agains
 t mis-assembly. Levy did his undergraduate studies in France. He received 
 his Ph.D. in 2008 from Cambridge University\, UK\, working at the MRC Labo
 ratory of Molecular Biology with Dr. Sarah Teichmann. For his post-doctora
 l research\, he joined the group of Prof. Stephen Michnick at the Universi
 ty of Montreal\, Canada. Since 2012\, he joined the Department of Chemical
  and Structural Biology at the Weizmann Institute in Israel\, where he is 
 now an Associate Professor. Levy was awarded the Blavatnick Award in Chemi
 stry (2020)\, the Wolf Foundation’s Krill Prize for Excellence in Scient
 ific Research (2018)\, the HFSP Career Development Award (2015)\, and the 
 Marie Curie Career Integration Award (2012).\n\n\n\nIMPORTANT NOTICE:\nAs 
 a consequence of the ongoing Covid-19 pandemic\, in-person attendance of t
 his seminar is subjected to some constraints:\n\n	Maximum number of partic
 ipants is limited to 80 (2/3 of room SV1717's nominal capacity): first com
 e\, first served!\n	Valid COVID certificate and ID\, required to enter the
  meeting room\, will be checked at the entrance\n	Face masks are mandatory
  for everyone in the seminar room (excepted the speaker while presenting).
 \n\nThank you warmly for your understanding!\n\nAlternatively\, the semina
 r can also be followed via Zoom web-streaming:\nZoom link (with one-time r
 egistration for the whole series) for attending remotely: https://go.epfl.
 ch/EPFLBioETalks\n\n\nInstructions for 1st-year Ph.D. students who are und
 er EDBB’s mandatory seminar attendance rule:\nIF you are not attending i
 n-person in the room\, please make sure to\n\n\n	send D. Reinhard a note b
 efore noon on seminar day\, informing that you plan to attend the talk onl
 ine\, and\n	be signed in on Zoom with a recognizable user name (not a pseu
 donym making it difficult or impossible to be identified).\n\nStudents att
 ending the seminar in-person should collect a confirmation signature after
  the talk - please print your own signature sheet beforehand (71 kB pdf av
 ailable for download here).
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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