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PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Flycodes: barcoding designer peptides for mass spectrometry enable
  in vivo antibody screening
DTSTART:20211102T161500
DTEND:20211102T174500
DTSTAMP:20260406T063903Z
UID:d70b34ee5b0d7db04fc0621a0cbc5f9c836edb1f1c5288113f658e7d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Markus Seeger (IMM - Universität Zürich)\nNestLink ena
 bles the simultaneous observation of potentially 1000s of unique proteins 
 via tagging with distinctive genetically-encoded peptides (flycodes)\, des
 igned for unambiguous detectability via liquid chromatography-mass spectro
 metry. We demonstrated the utility of NestLink to deep-mine nanobody pools
  for rare binders that recognize their membrane protein target in the cell
 ular context of pathogenic bacteria. In an attempt to reduce the burden of
  laboratory animals\, we show that flycodes facilitate the simultaneous de
 termination of individual PK/PD parameters and biodistribution in kidney a
 nd liver for a pool of over 100 unique nanobody constructs in a single ani
 mal. NestLink thus allows a broader range of biologic drug candidates to b
 e assayed in early stages of discovery\, thereby diminishing cost\, labor\
 , and ethical burdens.\n 
LOCATION:CH G1 495
STATUS:CONFIRMED
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