BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:GHI special seminar: What role does the immune system play in cont
 rolling the intestinal microbiota?
DTSTART:20211012T121500
DTEND:20211012T131500
DTSTAMP:20260501T195609Z
UID:099aac532c22311614c5210d9bbf9181924c11ffd4317baae1cb8e3b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Emma Slack\, Dep. of Health Sciences and Technology\, ETH Zür
 ich\nOur guts are home to a complex\, dense and dynamic consortia of micro
 bes\, which can have a profound impact on our health. How have we evolved 
 to promote species and microbial functions that are beneficial\, while min
 imizing the risk from common opportunistic pathogens such as Salmonella 
 and E.coli? Clearly the physiology of the intestinal tract\, including mo
 tility and secretions\, is a key determinant of microbiota health. Our wor
 k focuses on how intestinal immunity interacts with physiology of both the
  host and the microbes to manipulate microbiota composition and function (
 1\, 2). This reveals the potential for oral vaccine-based interventions th
 at may enable more robust prophylaxis of bacterial infections (3)\, as wel
 l as rational microbiota engineering.\n\n	High-avidity IgA protects the in
 testine by enchaining growing bacteria. Moor K\, Diard M\, Sellin ME\, Fe
 lmy B\, Wotzka SY\, Toska A\, Bakkeren E\, Arnoldini M\, Bansept F\, Dal C
 o A\, Völler T\, Minola A\, Fernandez-Rodriguez B\, Agatic G\, Barbieri S
 \, Piccoli L\, Casiraghi C\, Corti D\, Lanzavecchia A\, Regoes RR\, Loverd
 o C\, Stocker R\, Brumley* DR\, Hardt* W-D\, Slack* E. 2017. Nature 544:
 498–502 doi:10.1038/nature22058\n	Inflammation boosts bacteriophage tran
 sfer between Salmonella. Diard M\, Bakkeren E\, Cornuault JK\, Moor K\, H
 ausmann A\, Sellin ME\, Loverdo C\, Aertsen A\, Ackermann M\, De Paepe M\,
  Slack E\, Hardt W-D. 2017. Science355:1211-1215\, doi:10.1126/science.aa
 f8451 \n	A rationally designed oral vaccine induces immunoglobulin A in t
 he murine gut that directs the evolution of attenuated Salmonella variants
 .Diard M\, Bakkeren E\, Lentsch V\, Rocker A\, Bekele NA\, Hoces D\, Aslan
 i S\,Arnoldini M\,  Böhi F\, Schumann-Moor K\, Adamcik J\, Piccoli L\, L
 anzavecchia A\, Stadtmueller BM\, Donohue N\, van der Woude MW\, Hockenber
 ry A\, Viollier PH\, Falquet L\, Wüthrich D\, Bonfiglio F\, Loverdo C\, E
 gli A\, Zandomeneghi G\, Mezzeng R\, Holst O\, Meier BH\, Hardt WD\, Slack
  E. Nat Microbiol. 2021 May 27. doi:10.1038/s41564-021-00911-1.\n\nLabora
 tory for Food Immunology
LOCATION:https://epfl.zoom.us/meeting/register/tJAkfuyoqzsqEtxFujqV5KheYMC
 Urcg31IiS
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR