BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Dearomatization of indoles for the total synthesis of natural prod
 ucts
DTSTART:20211123T161500
DTEND:20211123T171500
DTSTAMP:20260506T061827Z
UID:b9e15ea4a0d24fca39bfb7b32e793b7435e579416675bb56a59625f0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Guillaume Vincent\, Université Paris-Sud\, France https:/
 /www.icmmo.u-psud.fr/fr/perso/guillaume-vincent/\nDearomatization of Indol
 es for the Total Synthesis of Natural Products\n\n\nGuillaume Vincent\nIns
 titut de Chimie Moléculaire et des Matériaux d’Orsay\nUniversité Pari
 s Saclay\, CNRS\n91405 Orsay\, France\nEmail: guillaume.vincent@universite
 -paris-saclay.fr\n\n\nWe aim to study the chemistry of the indole nucleus
  and to develop original strategies towards dearomatisation reactions of 
 indoles in order to obtain biologically relevant three dimensional scaff
 olds (“drug like”) and to achieve the total synthesis of indoline-cont
 aining natural products.1\,2 To this end\, we developed synthetic methods 
 via the Umpolung of N-Ac indoles and oxidative couplings of indoles.3\,4\n
 \n\n	Lachkar\, D. \; Denizot\, N.\; Poupon\, E.\; Evanno\, L.\; Vincent\,
  G. et al. Nat. Chem. 2017\, 9\, 793-798.\n	a) Jarret\, M.\; Tap\, A.\; Ko
 uklovsky\, C.\; Poupon\, E.\; Evanno\, L.\; Vincent\, G.  Angew. Chem. In
 t. Ed. 2018\, 57\, 12294-12298\; b) Jarret\, M.\; Turpin\, V.\; Tap\, A.\;
  Gallard\, J.-F.\; Kouklovsky\, C.\; Poupon\, E.\; Vincent\, G.\; Evanno\,
  L. Angew. Chem. Int. Ed. 2019\, 58\, 9861-9865\; c) Dou\, Y.\; Kouklovsky
 \, C.\; Gandon\, V.\; Vincent\, G. Angew. Chem. Int. Ed. 2020\, 59\, 1527.
 \n	a) Denizot\, N.\; Poulilhès\, A.\; Cucca\, M.\; Beaud\, R.\; Guillot\,
  R.\; Kouklovsky\, C.\; Vincent\, G. Org. Lett. 2014\, 16\, 5752-5755\; b)
  Tomakinian\, T.\; Guillot\, R.\; Kouklovsky\, C. Vincent\, G. Ang. Chem. 
 Int. Ed. 2014\, 53\, 11881-11885\; c) Beaud\, R.\; Guillot\, R.\; Kouklovs
 ky\, C. Vincent\, G. Ang. Chem. Int. Ed. 2012\, 51\, 12546-12550.\n	Wu\, J
 .\; Dou\, Y.\; Guillot\, R.\; Vincent\, G. J. Am. Chem. Soc. 2019\, 141\, 
 2832-2837.\n
LOCATION:AUDITOIRE CE1
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR