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SUMMARY:Mycobacterial Energetics in Response  to Slow Growth Rate and Hypo
 xia
DTSTART:20121001T110000
DTEND:20121001T120000
DTSTAMP:20260429T175741Z
UID:002af75fee78624a6ef61ed7c1164cc101e06e82eb88d43183d2ba0b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Pr Gregory Cook (University of Otago - Department of Microbiol
 ogy and Immunology) http://www.otago.ac.nz/genetics/staff/cook.html\nThe 
 mechanisms used by living cells to generate energy has fascinated physiolo
 gists for the past 50 years. Escherichia coli and mitochondria have been i
 mportant models for the elucidation of chemiosmotic principles in growing 
 cells. In obligately aerobic bacteria\, oxygen supply can quickly be exhau
 sted and cells are faced with the challenge of maintaining a membrane pote
 ntial and generating ATP at low oxygen. These bacteria are also faced with
  the challenge of adjusting their metabolic rate to be commensurate with t
 he anabolic rate to avoid bottlenecks in metabolism and overproduction of 
 reducing equivalents. We are using the genus Mycobacterium to study these 
 bioenergetic and metabolic questions to understand how these bacteria adap
 t to hypoxia. I will present our latest findings in this direction and dis
 cuss the concept of targeting energy generation for drug development again
 st intracellular pathogens.
LOCATION:SV 1717a http://plan.epfl.ch/?lang=fr&room=sv+1717a
STATUS:CONFIRMED
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