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VERSION:2.0
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SUMMARY:EPFL BioE Talks SERIES  "Single-Molecule Detection by Membrane Nan
 opores"
DTSTART:20211025T160000
DTEND:20211025T170000
DTSTAMP:20260405T201630Z
UID:a35936f365cfff30495ef6b05225693facec5bc8f83573bab4866900
CATEGORIES:Conferences - Seminars
DESCRIPTION:Chan Cao\, Ph.D.\, School of Life Sciences\, EPFL\, Lausanne (
 CH)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nNanopore is a powerful si
 ngle-molecule approach that allows the characterization of molecules of in
 terest in a label-free\, fast\, cheap\, and real-time way with sub-angstro
 m resolution and without any amplification in aqueous solutions. Membrane 
 nanopore has been successfully applied for sequencing long fragments of DN
 A and shown great potential for single-molecule proteomics applications an
 d next-generation information storage. I will first present our work aimed
  at tuning the structure of membrane nanopores towards a higher sensing re
 solution. By integrating experiments with molecular dynamics simulations\,
  we have systematically characterized the sensing region of the pore\, and
  then explored the structure-function relationship between the pore struct
 ure and its molecular sensing properties. Second\, we utilized the enginee
 red pore to decode digital information stored in tailored macromolecules w
 ith a single-bit resolution\, which provides an alternative reading and wr
 iting strategy for molecular digital data storage.\n\nBio:\nDr. Chan Cao r
 eceived her PhD in Analytical Chemistry from ECUST (Shanghai\, China) in 2
 017\, after which she worked as a postdoc fellow at EPFL. Chan currently i
 s an SNSF PRIMA fellow in the EPFL School of Life Sciences (SV). Her resea
 rch interests center around the development and application of advanced na
 notechnology to study the properties\, structure\, dynamic and function of
  biomolecules of interest at atomic and molecular level. In particular\, s
 he is specialized on nanopore single-molecule technology\, including engin
 eering and design of biological nanopores\, detection of protein biomarker
 s\, single-molecule protein sequencing\, and molecular digital data storag
 e. Chan has received the Annual Jeffrey Hubbell and Melody Swartz Young B
 ioengineer award in 2020\, Synapsis Career Development award in 2020\, Sha
 nghai Mayer award in 2017 and American Chemical Society Outstanding Gradua
 te Student Research award in 2016.\n\n\n\nIMPORTANT NOTICE:\nAs a conseque
 nce of the ongoing Covid-19 pandemic\, in-person attendance of this semina
 r is subjected to some constraints:\n\n	Maximum number of participants is 
 limited to 80 (2/3 of room SV1717's nominal capacity): first come\, first 
 served!\n	Valid COVID certificate and ID\, required to enter the meeting r
 oom\, will be checked at the entrance\n	Face masks are mandatory for every
 one in the seminar room (excepted the speaker while presenting).\n\nThank 
 you warmly for your understanding!\n\nAlternatively\, the seminar can also
  be followed via Zoom web-streaming:\nZoom link (with one-time registratio
 n for the whole series) for attending remotely: https://go.epfl.ch/EPFLBio
 ETalks\n\n\nInstructions for 1st-year Ph.D. students who are under EDBB’
 s mandatory seminar attendance rule:\nIF you are not attending in-person i
 n the room\, please make sure to\n\n\n	send D. Reinhard a note before noon
  on seminar day\, informing that you plan to attend the talk online\, and\
 n	be signed in on Zoom with a recognizable user name (not a pseudonym maki
 ng it difficult or impossible to be identified).\n\nStudents attending the
  seminar in-person should collect a confirmation signature after the talk 
 - please print your own signature sheet beforehand (71 kB pdf available fo
 r download here).
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://go.epfl.ch/
 EPFLBioETalks
STATUS:CONFIRMED
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