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SUMMARY:Pd-catalyzed Cross-couplings and Alternatives to Cross-couplings f
 or the (Enantioselective) Alpha Arylation of Aldehydes
DTSTART:20121205T171500
DTEND:20121205T183000
DTSTAMP:20260609T230124Z
UID:2a53747a46f7291f76a86c72af39e9c3e52d8e27226bd67d966a7bdf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Clément Mazet\, University of Geneva\, Switzerland\nDep
 ending upon the nature of the substrate the development of efficient trans
 ition-metal catalysts for the enantioselective enolate arylation is faced 
 with different but equally challenging issues. On one hand\, linear substr
 ates form tertiary alpha-aryl compounds which undergo facile epimerization
  under the basic conditions generally employed. On the other hand\, this p
 roblem can be circumvented if alpha-branched substrates are used\, but the
 se\, in turn\, demand the difficult stereoselective formation of more cong
 ested quaternary stereocenters.\n\nThe nature of the carbonyl functionalit
 y comes as a next challenge. Indeed\, there is an almost direct relationsh
 ip between its sensitivity and its synthetic potential and usefulness. In 
 short\, the most reactive and sensitive a carbonyl group is\, the more ver
 satile and synthetically useful it appears. As a consequence\, the catalyt
 ic asymmetric alpha-arylation of aldehydes is likely to be the most diffic
 ult arylation of enolates to develop.\n\nCurrent efforts in our group are 
 directed toward the development of methods for the direct (enantioselectiv
 e) alpha-arylation of aldehydes as well as the development of alternative 
 strategies leading to similar products. A particular emphasis is placed on
  understanding the mechanism that governs these transformations.Pd-catalyz
 ed Cross-couplings and Alternatives to Cross-couplings for the (Enantiosel
 ective) Alpha Arylation of Aldehydes
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
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