BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:EPFL BioE Talks SERIES "Engineering New-To-Nature Enzymes\, Synth etic Pathways and Artificial Cells for Sustainable Carbon Capture" DTSTART:20211101T160000 DTEND:20211101T170000 DTSTAMP:20260509T103401Z UID:49903fd92f3d98d9b51de64e5b93e31ac2c0a5e1a46794de4be20a0a CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. Tobias J. Erb\, Max Planck Institute for terrestrial Mic robiology\, Marburg (D)\nWEEKLY EPFL BIOE TALKS SERIES\n\nAbstract:\nCarbo n dioxide (CO2) is a potent greenhouse gas that is a critical factor in gl obal warming. At the same time atmospheric CO2 is a cheap and ubiquitous c arbon source. However\, synthetic chemistry lacks suitable catalysts to fu nctionalize atmospheric CO2\, emphasizing the need to understand and explo it the CO2 fixation mechanisms offered by Nature. In my talk I will discus s the evolution and limitation of naturally existing CO2 fixing enzymes an d present strategies how to discover and engineer novel enzymes and pathwa ys for the fixation of CO2 [1\,2]. I will exemplify how these enzymes can be used to realize efficient catalytic networks for the conversion of CO2 that outcompete those of natural photosynthesis [3]. Finally\, I will talk about the challenges of transplanting these synthetic networks into natur al and synthetic cells to create novel cell factories and catalytic system s for the capture and conversion of CO2 into value-added compounds [4\,5]. \n\nReferences:\n[1] Bernhardsgrütter I.\, et al. (2019) Awakening the s leeping carboxylase function of enzymes: Engineering the natural CO2-bindi ng potential of reductases. JACS 141:9778-9782\n[2] Scheffen M.\, et al. A new-to-nature carboxylation module to improve natural and synthetic CO2 f ixation. Nature Catalysis 4:105-115\n[3] Schwander T.\, et al. (2016) A sy nthetic pathway for the fixation of carbon dioxide in vitro. Science 354: 900-904\n[4] Miller T.E.\, Beneyton T. et al. (2020) Light-powered CO2 fix ation in a chloroplast mimic with natural and synthetic parts. Science 368 :649-654\n[5] Sundaram S.\, Diehl C. et al. (2021) A modular in vitro plat form for the production of terpenes and polyketides from CO2. Angew. Chem. Int. Ed.\, in press\n\nBio:\nTobias J. Erb is a synthetic biologist and D irector at the Max Planck Institute for terrestrial Microbiology in Marbur g\, Germany. Erb studied Chemistry and Biology at the University of Freibu rg (D) and the Ohio State University (USA). After a postdoctoral stay at t he University of Illinois (USA)\, Tobi headed a junior research group at E TH Zürich (CH)\, before he relocated to the Max Planck Institute for terr estrial Microbiology in Marburg\, where he was promoted to Director in 201 7.\nErb received numerous awards\, among them the Research Awards of the S wiss and the German Societies for Microbiology\, the Heinz Maier-Leibnitz Prize of the DFG and the Otto Bayer Award. He was named one of 12 up- and coming scientists by American Chemical Society’s C&EN in 2015 and electe d to the European Academy of Microbiology in 2019 and EMBO in 2021.\nResea rch in the lab of Tobi Erb centers on the discovery\, function and enginee ring of novel CO2 converting enzymes and their use in engineered and artif icial photosynthesis\, as well as the bottom-up design of synthetic chloro plasts and cells.\n\n\nZoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks\n\nIMPOR TANT NOTICE:\nThis seminar can be followed via Zoom web-streaming only\, ( following prior one-time registration through the link above).\n\n\n\nInst ructions for 1st-year Ph.D. students who are under EDBB’s mandatory semi nar attendance rule:\nPlease make sure to\n\n send D. Reinhard a note befo re noon on seminar day\, informing that you plan to attend the talk online \, and\n be signed in on Zoom with a recognizable user name (not a pseudon ym making it difficult or impossible to be identified).\n LOCATION:via Zoom web-streaming only https://go.epfl.ch/EPFLBioETalks http s://go.epfl.ch/EPFLBioETalks STATUS:CONFIRMED END:VEVENT END:VCALENDAR