BioE COLLOQUIA SERIES: "Shedding Light on Ciliary cAMP Signaling"
Event details
| Date | 25.11.2019 |
| Hour | 12:15 |
| Speaker | Prof. Dagmar Wachten, University of Bonn (D) |
| Location | |
| Category | Conferences - Seminars |
WEEKLY BIOENGINEERING COLLOQUIA SERIES
(sandwiches served)
Abstract:
Primary cilia are cellular antennae, orchestrating signal transduction in most mammalian cells. Cilia dysfunction leads to the development of severe human diseases, collectively termed ciliopathies. However, the underlying molecular mechanisms are ill-defined. Cilia constitute a unique subcellular compartment. A diffusion barrier and the ciliary transport machinery maintain a protein composition that is distinct from the cell body. Although cAMP signaling components are enriched in the cilium, the role of ciliary cAMP signaling remains enigmatic. We have developed approaches that allow to specifically analyze cAMP signaling in motile and non-motile cilia using optogenetics and, thereby, shed light on ciliary signaling.
Bio:
Academic qualifications
Postgraduate professional career
MIND THE UNUSUAL VENUE!
Zoom link for attending remotely: https://epfl.zoom.us/j/108788992
(sandwiches served)
Abstract:
Primary cilia are cellular antennae, orchestrating signal transduction in most mammalian cells. Cilia dysfunction leads to the development of severe human diseases, collectively termed ciliopathies. However, the underlying molecular mechanisms are ill-defined. Cilia constitute a unique subcellular compartment. A diffusion barrier and the ciliary transport machinery maintain a protein composition that is distinct from the cell body. Although cAMP signaling components are enriched in the cilium, the role of ciliary cAMP signaling remains enigmatic. We have developed approaches that allow to specifically analyze cAMP signaling in motile and non-motile cilia using optogenetics and, thereby, shed light on ciliary signaling.
Bio:
Academic qualifications
- 2014 Habilitation: Molecular Biomedicine, University of Bonn, Germany
- 2006 Doctorate: Dr. rer. nat., Biology (Biochemistry), University of Cologne, Germany
- 1998 - 2003 Diploma, Biology, University of Cologne, Germany
Postgraduate professional career
- 2017 - pres. Professor (W2) for Biophysical Imaging at the Institute of Innate Immunity, University of Bonn, Germany
- 2014 - 2017 Max Planck Research Group Leader (W2), Minerva Max Planck Research Group “Molecular Physiology”, Research Center caesar, Bonn, Germany
- 2009 - 2013 Project Group Leader, Research Group „Molecular Physiology“, caesar, an Institute of the Max Planck Society, Bonn, Germany
- 2007 - 2009 Postdoctoral research fellow, Laboratory of Molecular Signaling, Babraham Institute, Cambridge, UK
- 2006 Postdoc, Research Center Jülich, Germany
- 2003 - 2006 PhD thesis, Institute for Biological Information Processing, Prof. U.B. Kaupp, Research Center Jülich, Germany
MIND THE UNUSUAL VENUE!
Zoom link for attending remotely: https://epfl.zoom.us/j/108788992
Practical information
- Informed public
- Free
Organizer
- Prof. Giovanni D'Angelo, EPFL
Contact
- Institute of Bioengineering (IBI), Christina Mattsson