BioE COLLOQUIA SERIES: "Transforming 2D Nanomaterials for Medicine: From Bioelectronics to Pharmacology"
Event details
| Date | 14.10.2019 |
| Hour | 12:15 |
| Speaker | Prof. Kostas Kostarelos, University of Manchester (UK) |
| Location | |
| Category | Conferences - Seminars |
WEEKLY BIOENGINEERING COLLOQUIA SERIES
(sandwiches served)
Abstract:
The use of nanomaterials in medicine is growing at an unprecedented rate for a variety of therapeutic, diagnostic or combinatory applications. Graphene and other 2D materials possess properties that make them attractive materials for biomedical applications. What is needed today is the determination of the unique characteristics graphene and 2D materials possess and how to transform them into value and solution propositions for specific clinical challenges. This talk will attempt to illustrate how graphene-based 2-dimensional materials with their electrical performance and the suitability for integration into flexible devices can constitute a versatile platform that could help address many of the current challenges in neural interface design. An alternative graphene material configuration and application will also be described based on biological-grade graphene oxide (GO) sheet suspensions and their interaction with tissues of living animals (in vivo). The pharmacokinetic and toxicokinetic profile of the GO sheets in correlation with their physicochemical characteristics (thickness, lateral dimensions) can allow the determination of the critical parameters that can allows their further development towards the clinic.
Bio:
Dr. Kostarelos obtained his Diploma in Chemical Engineering and PhD from the Department of Chemical Engineering at Imperial College London, studying the steric stabilization of liposomes using block copolymer molecules. He carried out his postdoctoral training in various medical institutions in the United States and has worked closely with D. Papahadjopoulos (UCSF, USA), G. Sgouros (Memorial Sloan-Kettering, NY, USA) and R.G. Crystal (Weill Medical College of Cornell University, NY, USA). He was Assistant Professor of Genetic Medicine & Chemical Engineering in Medicine at Cornell University Weill Medical College when he relocated to the UK as the Deputy Director of Imperial College Genetic Therapies Centre in 2002. In 2003 he joined the Centre for Drug Delivery Research at the UCL School of Pharmacy as the Deputy Head of the Centre. He was promoted to the Personal Chair of Nanomedicine and Head of the Centre in 2007. The entire Nanomedicine Lab was embedded within the Faculty of Medical and Human Sciences and the National Graphene Institute at the University of Manchester in 2013. Kostas is currently Professor of Nanomedicine at the University of Manchester and Visiting Professor at UCL Faculty of Life Sciences.
He has been invited Fellow of the Royal Society of Chemistry (FRSC), Fellow of the Royal Society of Medicine (FRSM), and Fellow of the Royal Society of Arts (FRSA) all in the United Kingdom. In 2010 he was awarded the Japanese Society for the Promotion of Science (JSPS) Professorial Fellowship with the National Institute of Advanced Industrial Science and Technology (AIST) in Tsukuba, Japan. He has been included in the Highly Cited Researcher 2018 list (https://hcr.clarivate.com) in the Cross-Field category.
He is the Founding and Senior Editor of the journal Nanomedicine and sits on the Editorial Board of:
ACS Nano, Bioconjugate Chemistry (ACS), 2D Materials (IOP), 2D Materials & Applications (NPJ), Archives in Toxicology (Springer), Nanoscale Horizons (RSC), Journal of Visualized Experiments (JoVE), Applied Materials Today (Elsevier), The Journal of Liposome Research (Taylor & Francis).
Website: http://www.nanomedicinelab.com
Zoom link for attending remotely: https://epfl.zoom.us/j/606593502
(sandwiches served)
Abstract:
The use of nanomaterials in medicine is growing at an unprecedented rate for a variety of therapeutic, diagnostic or combinatory applications. Graphene and other 2D materials possess properties that make them attractive materials for biomedical applications. What is needed today is the determination of the unique characteristics graphene and 2D materials possess and how to transform them into value and solution propositions for specific clinical challenges. This talk will attempt to illustrate how graphene-based 2-dimensional materials with their electrical performance and the suitability for integration into flexible devices can constitute a versatile platform that could help address many of the current challenges in neural interface design. An alternative graphene material configuration and application will also be described based on biological-grade graphene oxide (GO) sheet suspensions and their interaction with tissues of living animals (in vivo). The pharmacokinetic and toxicokinetic profile of the GO sheets in correlation with their physicochemical characteristics (thickness, lateral dimensions) can allow the determination of the critical parameters that can allows their further development towards the clinic.
Bio:
Dr. Kostarelos obtained his Diploma in Chemical Engineering and PhD from the Department of Chemical Engineering at Imperial College London, studying the steric stabilization of liposomes using block copolymer molecules. He carried out his postdoctoral training in various medical institutions in the United States and has worked closely with D. Papahadjopoulos (UCSF, USA), G. Sgouros (Memorial Sloan-Kettering, NY, USA) and R.G. Crystal (Weill Medical College of Cornell University, NY, USA). He was Assistant Professor of Genetic Medicine & Chemical Engineering in Medicine at Cornell University Weill Medical College when he relocated to the UK as the Deputy Director of Imperial College Genetic Therapies Centre in 2002. In 2003 he joined the Centre for Drug Delivery Research at the UCL School of Pharmacy as the Deputy Head of the Centre. He was promoted to the Personal Chair of Nanomedicine and Head of the Centre in 2007. The entire Nanomedicine Lab was embedded within the Faculty of Medical and Human Sciences and the National Graphene Institute at the University of Manchester in 2013. Kostas is currently Professor of Nanomedicine at the University of Manchester and Visiting Professor at UCL Faculty of Life Sciences.
He has been invited Fellow of the Royal Society of Chemistry (FRSC), Fellow of the Royal Society of Medicine (FRSM), and Fellow of the Royal Society of Arts (FRSA) all in the United Kingdom. In 2010 he was awarded the Japanese Society for the Promotion of Science (JSPS) Professorial Fellowship with the National Institute of Advanced Industrial Science and Technology (AIST) in Tsukuba, Japan. He has been included in the Highly Cited Researcher 2018 list (https://hcr.clarivate.com) in the Cross-Field category.
He is the Founding and Senior Editor of the journal Nanomedicine and sits on the Editorial Board of:
ACS Nano, Bioconjugate Chemistry (ACS), 2D Materials (IOP), 2D Materials & Applications (NPJ), Archives in Toxicology (Springer), Nanoscale Horizons (RSC), Journal of Visualized Experiments (JoVE), Applied Materials Today (Elsevier), The Journal of Liposome Research (Taylor & Francis).
Website: http://www.nanomedicinelab.com
Zoom link for attending remotely: https://epfl.zoom.us/j/606593502
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson