retrieve:
Return the details about the given Event id.

list:
List all Event objects.

GET /api/v1/events/?format=api&offset=250&ordering=-last_modification_date
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept

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            "description": "<p>You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: <a href=\"https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488\">https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488</a>.<br>\r\n<br>\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any).  However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the <a href=\"mailto:[email protected]\">CECAM Event Manager</a> if you have any question.<br>\r\n<br>\r\n<strong>Description</strong><br>\r\n<br>\r\nG protein-coupled receptors (GPCRs) represent a vast and diverse class of transmembrane proteins that orchestrate a wide range of physiological processes by responding to both endogenous and exogenous ligands [1,2]. These receptors are essential to critical functions such as metabolism, immune regulation, neuronal signaling, and sensory perception - including vision and olfaction. Due to their physiological relevance and membrane accessibility, GPCRs are the targets of approximately 34% of all prescribed medications, accounting for nearly 27% of the global pharmaceutical market [3]. <br>\r\nDespite their pharmaceutical importance, key aspects of GPCR function remain elusive. The canonical activation model posits that agonist binding to the extracellular orthosteric site triggers allosteric changes - most notably, the outward displacement of transmembrane helices 5 (TM5) and 6 (TM6) on the intracellular side - ultimately leading to receptor activation [2-4]. However, recent evidence suggests a more nuanced mechanism. In several GPCRs, activation appears to involve cooperative engagement between the agonist and the G protein. For example, the G protein may disrupt an \"inactivating ionic lock\" - a salt bridge between TM3 and TM6 - while the agonist stabilizes the active conformation. In some receptors, this is complemented by the formation of an “activating ionic lock” between TM5 and TM6 [5-8]. These dual contributions are considered thermodynamically essential for full activation [7].<br>\r\nAdding further complexity, GPCR activity is regulated by conformational microswitches and finely tuned intra-protein interaction networks. These dynamic rearrangements are difficult to capture and often elude direct correlation with functional outcomes. Moreover, allosteric ligands - which bind sites distinct from the orthosteric pocket - are being increasingly identified [9-12], along with small molecules capable of biased signaling, i.e., preferential activation of specific intracellular pathways [11-13, 16, 17]. These findings reveal a rich and underexplored conformational landscape that governs GPCR signaling. In addition, native membrane components—such as lipids and interacting proteins, including GPCR oligomers—are known to significantly modulate receptor function [11, 18-22].<br>\r\nTo disentangle these intricacies, computational modeling has become indispensable, offering atomistic insight into GPCR conformational dynamics and mechanistic understanding [1-2, 7, 11, 14, 16–21, 23]. Nevertheless, key questions remain - particularly regarding the structural basis of biased signaling, strategies for leveraging allosteric networks in pharmacology, and the modulatory role of the lipid environment. Addressing these gaps is crucial for both fundamental biology and the rational design of next-generation GPCR-targeting drugs with improved selectivity and safety profiles. <br>\r\nThese scientific challenges form the foundation of our upcoming workshop, which will focus on the latest experimental and computational approaches for studying the functional dynamics of GPCRs. Given the profound health, economic, and societal implications of modulating these receptors with precision, we aim to strengthen the interdisciplinary nature of the event by increasing the representation of experimental research and integrating cutting-edge artificial intelligence applications into the program.<br>\r\nBuilding upon the success of the 2022 and 2024 editions - which led to new collaborations and a landmark publication in <em>Nature Reviews Drug Discovery</em> [24] - our goal is to further enhance communication and collaboration between experimentalists and theoreticians. The workshop will serve as a reference point for young scientists and students, offering a platform to interact with leading international experts. We are confident that this initiative will foster insightful discussions and contribute meaningfully to advancing the field of GPCR pharmacology.<br>\r\n<br>\r\n<strong>References</strong><br>\r\n<br>\r\n<a href=\"https://doi.org/10.1038/nrd.2017.229\" target=\"_blank\">[1] J. Smith, R. Lefkowitz, S. Rajagopal, Nat. Rev. Drug. Discov., <strong>17</strong>, 243-260 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-024-01083-3\" target=\"_blank\">[2] P. Conflitti, E. Lyman, M. Sansom, P. Hildebrand, H. Gutiérrez-de-Terán, P. Carloni, T. Ansell, S. Yuan, P. Barth, A. Robinson, C. Tate, D. Gloriam, S. Grzesiek, M. Eddy, S. Prosser, V. Limongelli, Nat. Rev. Drug. Discov., <strong>24</strong>, 251-275 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41589-024-01682-6\" target=\"_blank\">[3] L. Picard, A. Orazietti, D. Tran, A. Tucs, S. Hagimoto, Z. Qi, S. Huang, K. Tsuda, A. Kitao, A. Sljoka, R. Prosser, Nat. Chem. Biol., <strong>21</strong>, 71-79 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.drudis.2020.10.006\" target=\"_blank\">[4] B. Huang, C. St. Onge, H. Ma, Y. Zhang, Drug Discovery Today, <strong>26</strong>, 189-199 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-023-42082-z\" target=\"_blank\">[5] D. Di Marino, P. Conflitti, S. Motta, V. Limongelli, Nat. Commun., <strong>14</strong>, 6439 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.ceb.2018.10.007\" target=\"_blank\">[6] G. Milligan, R. Ward, S. Marsango, Current Opinion in Cell Biology, <strong>57</strong>, 40-47 (2019)</a><br>\r\n<a href=\"https://doi.org/10.7554/elife.73901\" target=\"_blank\">[7] S. Huang, O. Almurad, R. Pejana, Z. Morrison, A. Pandey, L. Picard, M. Nitz, A. Sljoka, R. Prosser, eLife, <strong>11</strong>, (2022)</a><br>\r\n<a href=\"https://doi.org/10.1146/annurev-pharmtox-010919-023411\" target=\"_blank\">[8] A. Duncan, W. Song, M. Sansom, Annu. Rev. Pharmacol. Toxicol., <strong>60</strong>, 31-50 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-60003-0\" target=\"_blank\">[9] A. Morales-Pastor, T. Miljuš, M. Dieguez-Eceolaza, T. Stępniewski, V. Ledesma-Martin, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, D. Sykes, C. Nicholson, E. Koers, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent, Nat. Commun., <strong>16</strong>, 5265 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-022-05588-y\" target=\"_blank\">[10] A. Faouzi, H. Wang, S. Zaidi, J. DiBerto, T. Che, Q. Qu, M. Robertson, M. Madasu, A. El Daibani, B. Varga, T. Zhang, C. Ruiz, S. Liu, J. Xu, K. Appourchaux, S. Slocum, S. Eans, M. Cameron, R. Al-Hasani, Y. Pan, B. Roth, J. McLaughlin, G. Skiniotis, V. Katritch, B. Kobilka, S. Majumdar, Nature, <strong>613</strong>, 767-774 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-022-31652-2\" target=\"_blank\">[11] M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, E. Dean, C. Hume, S. Hayward, J. Oliver, F. Zhao, D. Spanswick, C. Reynolds, M. Lochner, G. Ladds, B. Frenguelli, Nat. Commun., <strong>13</strong>, 4150 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41580-018-0049-3\" target=\"_blank\">[12] D. Wootten, A. Christopoulos, M. Marti-Solano, M. Babu, P. Sexton, Nat. Rev. Mol. Cell. Biol., <strong>19</strong>, 638-653 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-017-0011-7\" target=\"_blank\">[13] D. Hilger, M. Masureel, B. Kobilka, Nat. Struct. Mol. Biol., <strong>25</strong>, 4-12 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-57034-y\" target=\"_blank\">[14] D. Aranda-García, T. Stepniewski, M. Torrens-Fontanals, A. García-Recio, M. Lopez-Balastegui, B. Medel-Lacruz, A. Morales-Pastor, A. Peralta-García, M. Dieguez-Eceolaza, D. Sotillo-Nuñez, T. Ding, M. Drabek, C. Jacquemard, J. Jakowiecki, W. Jespers, M. Jiménez-Rosés, V. Jun-Yu-Lim, A. Nicoli, U. Orzel, A. Shahraki, J. Tiemann, V. Ledesma-Martin, F. Nerín-Fonz, S. Suárez-Dou, O. Canal, G. Pándy-Szekeres, J. Mao, D. Gloriam, E. Kellenberger, D. Latek, R. Guixà-González, H. Gutiérrez-de-Terán, I. Tikhonova, P. Hildebrand, M. Filizola, M. Babu, A. Di Pizio, S. Filipek, P. Kolb, A. Cordomi, T. Giorgino, M. Marti-Solano, J. Selent, Nat. Commun., <strong>16</strong>, 2020 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-018-0259-z\" target=\"_blank\">[15] D. Thal, A. Glukhova, P. Sexton, A. Christopoulos, Nature, <strong>559</strong>, 45-53 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.tips.2020.12.005\" target=\"_blank\">[16] L. Slosky, M. Caron, L. Barak, Trends in Pharmacological Sciences, <strong>42</strong>, 283-299 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.apsb.2023.07.020\" target=\"_blank\">[17] C. Zhu, X. Lan, Z. Wei, J. Yu, J. Zhang, Acta Pharmaceutica Sinica B, <strong>14</strong>, 67-86 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.chempr.2024.08.004\" target=\"_blank\">[18] V. D’Amore, P. Conflitti, L. Marinelli, V. Limongelli, Chem, <strong>10</strong>, 3678-3698 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41557-023-01238-6\" target=\"_blank\">[19] A. Mafi, S. Kim, W. Goddard, Nat. Chem., <strong>15</strong>, 1127-1137 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-024-01334-2\" target=\"_blank\">[20] H. Batebi, G. Pérez-Hernández, S. Rahman, B. Lan, A. Kamprad, M. Shi, D. Speck, J. Tiemann, R. Guixà-González, F. Reinhardt, P. Stadler, M. Papasergi-Scott, G. Skiniotis, P. Scheerer, B. Kobilka, J. Mathiesen, X. Liu, P. Hildebrand, Nat. Struct. Mol. Biol., <strong>31</strong>, 1692-1701 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2015.04.043\" target=\"_blank\">[21] A. Manglik, T. Kim, M. Masureel, C. Altenbach, Z. Yang, D. Hilger, M. Lerch, T. Kobilka, F. Thian, W. Hubbell, R. Prosser, B. Kobilka, Cell, <strong>161</strong>, 1101-1111 (2015)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2020.03.003\" target=\"_blank\">[22] M. Congreve, C. de Graaf, N. Swain, C. Tate, Cell, <strong>181</strong>, 81-91 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-025-01139-y\" target=\"_blank\">[23] J. Lorente, A. Sokolov, G. Ferguson, H. Schiöth, A. Hauser, D. Gloriam, Nat. Rev. Drug. Discov., <strong>24</strong>, 458-479 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1111/bph.16495\" target=\"_blank\">[24] M. Lopez‐Balastegui, T. Stepniewski, M. Kogut‐Günthel, A. Di Pizio, M. Rosenkilde, J. Mao, J. Selent, British. J. Pharmacology., <strong>182</strong>, 3211-3224 (2024)</a>\r\n</p><div class=\"active tab-pane\"> </div>",
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            "cancel_reason": "Changement de date",
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                "id": 15,
                "code": "FORM",
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            "id": 68778,
            "title": "ERC Synergy Grants",
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            "keywords": "",
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            "category": {
                "id": 16,
                "code": "PROP",
                "fr_label": "Appel à proposition",
                "en_label": "Call for proposal",
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            "id": 70385,
            "title": "Préparer sa vie post-professionnelle",
            "slug": "preparer-sa-vie-post-professionnelle-5",
            "event_url": "https://memento.epfl.ch/event/preparer-sa-vie-post-professionnelle-5",
            "visual_url": "https://memento.epfl.ch/image/31844/200x112.jpg",
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            "lang": "en",
            "start_date": "2026-11-02",
            "end_date": "2026-11-03",
            "start_time": "08:45:00",
            "end_time": "16:30:00",
            "description": "<p>Prendre sa retraite après un long parcours professionnel ne va pas forcément de soi, si l'on pense à la place prise par le travail dans son parcours de vie. Le séminaire a pour objectif d'aider les participant.e.s à identifier les changement que cette transition introduira dans leur existence, afin d'anticiper et construire un nouvel équilibre de vie. Il s'agit également de conscientiser tous les aspects de cette période de la vie et les adaptations à réaliser, seul.e ou en couple, ainsi qui de définir les axes principaux et futures activités et projets. Les questions liées aux aspects financiers et au maintien de son capital santé, sont aussi abordées.</p>",
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            "creation_date": "2025-11-11T16:07:20",
            "last_modification_date": "2025-11-17T12:53:37",
            "link_label": "Inscription",
            "link_url": "https://epfl.eu.crossknowledge.com/site/m/public_training/705",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "",
            "url_place_and_room": "",
            "url_online_room": "",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/1/?format=api"
            ],
            "speaker": "AvantAge",
            "organizer": "KeepLearning",
            "contact": "[email protected]",
            "is_internal": "True",
            "theme": "",
            "vulgarization": {
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                "fr_label": "Tout public",
                "en_label": "General public"
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            "registration": {
                "id": 1,
                "fr_label": "Sur inscription",
                "en_label": "Registration required"
            },
            "keywords": "",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/118551/",
            "category": {
                "id": 15,
                "code": "FORM",
                "fr_label": "Formations internes",
                "en_label": "Internal trainings",
                "activated": true
            },
            "academic_calendar_category": null,
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        },
        {
            "id": 70194,
            "title": "COST",
            "slug": "cost",
            "event_url": "https://memento.epfl.ch/event/cost",
            "visual_url": "https://memento.epfl.ch/image/31649/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/31649/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/31649/max-size.jpg",
            "lang": "en",
            "start_date": "2026-10-30",
            "end_date": "2026-10-30",
            "start_time": null,
            "end_time": null,
            "description": "<strong>Call currently closed<br>\r\n<a href=\"https://www.google.com/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=&amp;cad=rja&amp;uact=8&amp;ved=2ahUKEwjq14HX8MjuAhXSiqQKHe8pDHQQFjAAegQIBhAC&amp;url=https%3A%2F%2Fwww.cost.eu%2F&amp;usg=AOvVaw1onEGi7vjLjH7u6Q2FPmNB\">COST</a> (European Cooperation in Science and Technology)</strong> is a funding programme that encourages networking of scientific and technological research activities throughout Europe and beyond. The aim is to facilitate breakthrough scientific developments leading to new concepts and products. COST does not fund research but supports networking (COST Actions) via different tools such as meetings, short-term scientific exchanges, training schools and dissemination activities. COST Actions have a duration of 4 years. The deadline to submit a COST Action is usually in October. COST Actions do not cover research funding. Integration into existing COST actions is possible.<br>\r\n<br>\r\nSwitzerland is one of the founding countries of COST and a full member of the COST Association. Thanks to this status, researchers in Switzerland are entitled to participate in COST Actions or to coordinate them and submit applications for new Actions. Thus, scientists based in Switzerland are fully eligible for all COST activities and for reimbursement of their related expenses.<br>\r\nSNSF provides support for the proposal preparation for COST Actions.<br>\r\n<br>\r\nFind information about open calls and guidelines on <a href=\"https://www.cost.eu/\"><strong>COST Europe</strong></a><br>\r\nContact <a href=\"https://www.snf.ch/en/EpxgsoxjZBQv6id1/funding/programmes/cost\"><strong>SNSF COST webpage</strong></a> for support services.<br>\r\nSNSF Contact: Ladina Knapp,<strong> </strong><a href=\"mailto:[email protected]\">[email protected]</a><strong>  </strong><br>\r\nContact <a href=\"mailto:[email protected]\">[email protected]</a> for questions<br>\r\n<br>\r\n ",
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            "link_label": "",
            "link_url": "",
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            "cancel_reason": "",
            "place_and_room": "",
            "url_place_and_room": "",
            "url_online_room": "",
            "spoken_languages": [],
            "speaker": "",
            "organizer": "",
            "contact": "[email protected]",
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            "vulgarization": {
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                "fr_label": "Tout public",
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            },
            "registration": {
                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
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            "keywords": "",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/118257/",
            "category": {
                "id": 16,
                "code": "PROP",
                "fr_label": "Appel à proposition",
                "en_label": "Call for proposal",
                "activated": true
            },
            "academic_calendar_category": null,
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            "mementos": [
                "https://memento.epfl.ch/api/v1/mementos/140/?format=api"
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        },
        {
            "id": 66918,
            "title": "Spring Semester",
            "slug": "spring-semester-3",
            "event_url": "https://memento.epfl.ch/event/spring-semester-3",
            "visual_url": "https://memento.epfl.ch/image/28624/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/28624/720x405.jpg",
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            "lang": "en",
            "start_date": "2027-02-22",
            "end_date": "2027-02-22",
            "start_time": null,
            "end_time": null,
            "description": "",
            "image_description": "",
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            "last_modification_date": "2025-04-15T21:45:17",
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            "link_url": "",
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            "cancel_reason": "",
            "place_and_room": "",
            "url_place_and_room": "",
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            "speaker": "",
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                "fr_label": "Entrée libre",
                "en_label": "Free"
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            "keywords": "",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/113404/",
            "category": {
                "id": 4,
                "code": "DIVERS",
                "fr_label": "Autres types d’événement",
                "en_label": "Miscellaneous",
                "activated": true
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            "academic_calendar_category": null,
            "domains": [],
            "mementos": [
                "https://memento.epfl.ch/api/v1/mementos/391/?format=api"
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            "id": 66921,
            "title": "ENAC Week",
            "slug": "enac-week-16",
            "event_url": "https://memento.epfl.ch/event/enac-week-16",
            "visual_url": "https://memento.epfl.ch/image/28627/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/28627/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/28627/max-size.jpg",
            "lang": "en",
            "start_date": "2027-05-10",
            "end_date": "2027-05-14",
            "start_time": null,
            "end_time": null,
            "description": "",
            "image_description": "",
            "creation_date": "2024-09-13T10:43:49",
            "last_modification_date": "2024-09-13T10:44:23",
            "link_label": "",
            "link_url": "",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "",
            "url_place_and_room": "",
            "url_online_room": "",
            "spoken_languages": [],
            "speaker": "",
            "organizer": "<a href=\"http://enac.epfl.ch\">ENAC</a>",
            "contact": "<a href=\"http://enac.epfl.ch\">ENAC</a>",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 1,
                "fr_label": "Tout public",
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            },
            "registration": {
                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
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            "keywords": "",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/113416/",
            "category": {
                "id": 4,
                "code": "DIVERS",
                "fr_label": "Autres types d’événement",
                "en_label": "Miscellaneous",
                "activated": true
            },
            "academic_calendar_category": null,
            "domains": [],
            "mementos": [
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}