retrieve:
Return the details about the given Event id.

list:
List all Event objects.

GET /api/v1/events/?format=api&offset=30&ordering=event__url_link
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept

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            "title": "Seminar in Finance",
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            "lang": "en",
            "start_date": "2027-05-21",
            "end_date": "2027-05-21",
            "start_time": "11:00:00",
            "end_time": "12:15:00",
            "description": "",
            "image_description": "",
            "creation_date": "2026-06-03T15:45:32",
            "last_modification_date": "2026-06-03T15:45:32",
            "link_label": "",
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            "speaker": "<a href=\"https://mitsloan.mit.edu/faculty/directory/leonid-kogan\">Leonid Kogan - MIT</a>",
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            "id": 72102,
            "title": "Seminar in Finance",
            "slug": "seminar-in-finance-37",
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            "lang": "en",
            "start_date": "2027-03-12",
            "end_date": "2027-03-12",
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            "end_time": "12:15:00",
            "description": "",
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            "creation_date": "2026-06-12T12:57:20",
            "last_modification_date": "2026-08-31T14:50:08",
            "link_label": "",
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            "speaker": "Morten Bennedsen - University of Copenhagen",
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            "id": 72194,
            "title": "Neuro-X seminar: Prof Tim O'Shea - Engineering astrocytes to promote wound repair and modulate foreign body responses in the CNS",
            "slug": "neuro-x-seminar-prof-tim-o-shea-engineering-astroc",
            "event_url": "https://memento.epfl.ch/event/neuro-x-seminar-prof-tim-o-shea-engineering-astroc",
            "visual_url": "https://memento.epfl.ch/image/33474/200x112.jpg",
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            "start_date": "2026-10-09",
            "end_date": "2026-10-09",
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            "end_time": "12:00:00",
            "description": "<p>Astrocytes are the predominant glial cells in the mammalian central nervous system (CNS) and play essential roles in maintaining neural circuit activity and tissue homeostasis. In response to CNS insult, including traumatic injury or implantation of a medical device, astrocytes undergo a conserved, temporally regulated reprogramming that reshapes their prioritized functions to protect adjacent neural tissue. The nature and extent of astrocyte reprogramming critically influences outcomes after CNS insult. For example, regeneration after traumatic CNS injury in adult mammals is limited by local responding astrocytes lacking sufficient self-renewal capacity. By contrast, the CNS of neonate (newborn) mammals possesses exceptional parenchymal repair capacity owing to immature astrocytes with elevated proliferative and migratory potential. In the context of an implanted medical device, the spatial extent of astrocyte reprogramming and how impacted astrocytes respond to any further device micromotion, latent infection, or other persistent device-derived stimuli, dictates device performance and longevity. Engineering astrocyte responses to promote targeted functional gains while preserving key capabilities of healthy neural tissue astrocytes will be critical to enabling effective neural regeneration therapies and improving long-term performance of implanted devices. In this talk, I will outline our emerging understanding of how adult astrocytes adaptively reprogram in response to CNS injury and implanted foreign bodies, drawing insights from innovative astrocyte-specific transcriptomic bioassays. I will also provide an overview of biomaterial and cell-grafting strategies that we are exploring to direct astrocyte responses in preclinical models of stroke, spinal cord injury, and foreign body responses.<br>\r\n<br>\r\n<strong>Bio:</strong><br>\r\n<strong>Dr. Timothy O’Shea, PhD</strong> is an Assistant Professor in the Biomedical Engineering department at Boston University (BU). Tim grew up in Brisbane, Australia and completed a Bachelor of Medical Engineering (First Class Honours) and a Masters in Engineering Management at Queensland University of Technology (QUT) before moving to the US for graduate school. He completed his PhD study in Medical Engineering and Medical Physics within the collaborative Health Sciences and Technology program of the Harvard Medical School and the Massachusetts Institute of Technology where we conducted PhD thesis research with Institute Professor Robert Langer. As a Postdoctoral Fellow in Neurobiology at UCLA, he worked with Professors Michael Sofroniew (Neurobiology) and Timothy Deming (Bioengineering) developing and testing novel bioengineering tools to study biological mechanisms involved in CNS injury and repair as well as the CNS foreign body response to implants. Since Fall 2020 he has been leading the Glia Engineering Lab at BU where he has received numerous awards including the Maximizing Investigators' Research Award (MIRA) from NIH and grants from several spinal cord injury research foundations such as Craig H Neilsen, Paralyzed Veterans of America, Bryon Reisch, and Wings for Life.</p>",
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            "speaker": "<a href=\"https://www.bu.edu/eng/profile/timothy-oshea-ph-d/\">Tim O'Shea</a>",
            "organizer": "<a href=\"http://people.epfl.ch/mark.anderson\">Mark Anderson</a>",
            "contact": "<a href=\"https://people.epfl.ch/niels.lion?lang=en\">Niels Lion</a>",
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        {
            "id": 72211,
            "title": "QSE Innovation Seed Grants",
            "slug": "qse-innovation-seed-grants",
            "event_url": "https://memento.epfl.ch/event/qse-innovation-seed-grants",
            "visual_url": "https://memento.epfl.ch/image/33491/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/33491/720x405.jpg",
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            "lang": "en",
            "start_date": "2026-07-07",
            "end_date": "2027-05-31",
            "start_time": null,
            "end_time": null,
            "description": "<strong>The <a href=\"https://www.epfl.ch/research/domains/quantum-center/funding/qse-innovation-seed-grants/\">QSE Innovation Seed Grant</a> is open for applications!</strong><br>\r\n<br>\r\nThis is a unique seed funding opportunity of up to CHF 25k to encourage the brightest ideas for cutting-edge applications, technology transfer, and start-up creation in the field of quantum science and engineering, open to master’s students and researchers, including PhD students and post docs, in the initial phase of developing a cutting-edge application, product or service with a real societal impact. <br>\r\n<br>\r\nAwardees of this QSE innovation seed grant will have a first opportunity, for example through coaching, workshops or mission trainings (e.g. <a href=\"https://www.epfl.ch/innovation/students-innovation-lab/epfl-changemakers/\">EPFL Changemakers</a>), to validate their project idea and get ready for future innovation funding programs.<br>\r\n<br>\r\nMain requirements\r\n<ul>\r\n\t<li>Only graduate students or researchers hosted or employed at an EPFL lab or unit are eligible to apply and act as Principal Investigator (PI). The head of the host lab has to co-sign the application form, and expressing as such their support of the project proposal.</li>\r\n\t<li>QSE innovation seed funding cannot be used for basic research or as general funding for the PI’s host lab. It can only be used for applicable planned projects in the field of quantum science and engineering with high innovation potential for business and society offering concrete solutions to problems. A main driver to determine eligible projects is the attractivity towards industrial partners and the technology transfer traction. We commit to considering all high potential translational projects and ideas, even if they have not yet filed Intellectual Property.</li>\r\n\t<li>Projects can be co-sponsored by third parties (e.g., federal government, cantons, foundations, business acting as a potential licensee).</li>\r\n</ul>\r\nHow to apply\r\n\r\n<ul>\r\n\t<li>PIs interested in submitting an application should contact, prior to drafting or submitting an application, the call coordinator Charlotte Vandenberghe (<a href=\"mailto:[email protected]\">[email protected]</a>). </li>\r\n\t<li>Candidates can submit their application on a continuous basis. \r\n\t<ul>\r\n\t\t<li>Applications will be reviewed in a timely manner; applicants will be informed about the outcome via email.</li>\r\n\t\t<li>The project should start within the 6 months after approval.</li>\r\n\t</ul>\r\n\t</li>\r\n\t<li>Please download and use the provided template from <a href=\"https://www.epfl.ch/research/domains/quantum-center/funding/qse-innovation-seed-grants/\">the website.</a></li>\r\n\t<li>Proposals should be submitted via email: <a href=\"mailto:[email protected]\">[email protected]</a></li>\r\n\t<li>Please add “QSE Innovation Seed Grant application_NAME PI” in the title of the email.</li>\r\n</ul>\r\n<strong>Rolling deadline</strong>",
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        {
            "id": 72248,
            "title": "Quantum-Classical Synergies for Simulations of Quantum Systems",
            "slug": "quantum-classical-synergies-for-simulations-of-q-2",
            "event_url": "https://memento.epfl.ch/event/quantum-classical-synergies-for-simulations-of-q-2",
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            "lang": "en",
            "start_date": "2026-10-30",
            "end_date": "2026-10-30",
            "start_time": "15:00:00",
            "end_time": null,
            "description": "<p>Thesis Director: Prof. G. Carleo,<br>\r\nPhysics doctoral program<br>\r\nThesis Nr. 12057<br>\r\n<br>\r\nTo take part in the public defense, please contact directly the speaker</p>",
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            "creation_date": "2026-07-16T14:35:09",
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            "spoken_languages": [],
            "speaker": "<strong>Gian Florin GENTINETTA</strong>",
            "organizer": "",
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            "keywords": "EDPY",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/121284/",
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                "id": 12,
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        {
            "id": 72531,
            "title": "Slip pulse earthquakes",
            "slug": "slip-pulse-earthquakes",
            "event_url": "https://memento.epfl.ch/event/slip-pulse-earthquakes",
            "visual_url": "https://memento.epfl.ch/image/33771/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/33771/720x405.jpg",
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            "lang": "en",
            "start_date": "2026-10-12",
            "end_date": "2026-10-12",
            "start_time": "12:15:00",
            "end_time": "13:15:00",
            "description": "<strong>Abstract</strong>:<br>\r\nThe spatiotemporal dynamics of frictional systems, ranging from engineering interfaces in mechanical joints to tectonic faults that host earthquakes, are governed by the propagation of interfacial rupture. A prominent rupture mode is self-healing slip pulses, which feature a finite slipping zone. The physics of slip pulses is qualitatively different from their expanding crack-like counterparts, as they involve the interplay between leading-edge contact breakage and trailing-edge re-strengthening (healing). The latter is intrinsically related to generic properties of frictional interactions at contacting interfaces, absent in ordinary fracture of bulk materials. In this talk, I will review a recently developed theory of two-dimensional slip pulses, which revealed intriguing dynamical properties of slip pulses and provided extensive predictions for their spatiotemporal evolution. The theoretical predictions are supported by large-scale numerical simulations and, more recently, by extensive laboratory experiments. The implications and potential applications of the theory will be discussed as time permits. <br>\r\n<br>\r\n<strong>References</strong>:\r\n<ol>\r\n\t<li><a href=\"https://www.pnas.org/doi/10.1073/pnas.2309374120\" target=\"_blank\" title=\"open  in new window\">The dynamics of unsteady frictional slip pulses</a> [PNAS 120, e2309374120 (2023)]</li>\r\n\t<li><a href=\"https://www.sciencedirect.com/science/article/pii/S0012821X26000142\" target=\"_blank\" title=\"open in a new window\">An equation of motion for unsteady frictional slip pulses</a> [EPSL 678, 119831 (2026)]</li>\r\n\t<li><a href=\"https://arxiv.org/abs/2608.26065\" target=\"_blank\" title=\"open in a new window\">Lab earthquakes confirm the theory of frictional slip pulses</a> [arXiv:2608.26065 (2026)]</li>\r\n</ol>\r\n<br>\r\n<strong>Biography:</strong><br>\r\nEran Bouchbinder is a Professor at Weizmann Institute of Science, Israel. He leads a theoretical physics group who studies various non-equilibrium phenomena in spatially extended systems, addressing basic problems in statistical physic, condensed-matter physics, biophysics, materials physics, and geophysics. His work also involves close collaborations with computational and experimental groups.<br>\r\n<br>\r\n ",
            "image_description": "",
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            "speaker": "Eran Bouchbinder, Professor at Weizmann Institute of Science, Israel",
            "organizer": "LSMS",
            "contact": "Prof. Jean-François Molinari",
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        {
            "id": 72294,
            "title": "Volkswagen Stiftung | “Dual Use” of Ideas and Concepts from the Humanities and Social Sciences",
            "slug": "volkswagen-stiftung-dual-use-of-ideas-and-concepts",
            "event_url": "https://memento.epfl.ch/event/volkswagen-stiftung-dual-use-of-ideas-and-concepts",
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            "start_date": "2026-10-06",
            "end_date": "2026-10-06",
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            "description": "<strong>Aim: </strong>Concepts from the humanities and social sciences often have an impact far beyond academia. But what happens when theories and conceptual frameworks are de-contextualised and used for purposes other than those originally intended? Through this call for proposals, the Foundation supports research on such “dual use” effects and explores how the transfer of ideas from academia into political and ideological contexts takes place.<br>\r\n<br>\r\nResearch on the following topics is eligible for funding:\r\n<ul>\r\n\t<li>The occurrence, nature and manifestations of a specific ‘dual use’ of concepts and theories in the humanities and social sciences, which differs from deliberate disinformation or merely a simplified reception. What are its characteristic practices?</li>\r\n\t<li>Characteristics of theories and concepts in the humanities and social sciences that facilitate their ideologically motivated repurposing. What might a reception-sensitive approach to theory-building look like without restricting the freedom of research and teaching?</li>\r\n\t<li>Pathways of transfer and networks of actors through which ideas from the humanities and social sciences move from academic contexts into political, ideological or digital public spheres.</li>\r\n\t<li>Conditions under which such reinterpretations have a particular impact – for example, in the interplay of academic debates, media dynamics and political interests.</li>\r\n\t<li>Consequences arising from this for science communication in the humanities and social sciences. How can complex or critical concepts be communicated without them being easily oversimplified, misunderstood or ideologically exploited in public debates?</li>\r\n</ul>\r\n<br>\r\nFunding is available for (interdisciplinary) project teams from the humanities, cultural studies and social sciences, consisting of two to three researchers (one PI and up to two Co-PIs).<br>\r\n<br>\r\n<strong>Funding</strong>: up to EUR 650K<br>\r\n<br>\r\n<strong>Duration</strong>: max. 2 years<br>\r\n<br>\r\n<strong>Eligibility:</strong> The call for proposals is aimed at researchers with a PhD who are employed at German universities and research institutions. Researchers with a PhD <strong>from international research institutions may participate as Co-PIs.</strong><br>\r\n<br>\r\n<strong>How to Apply</strong>: Applicants must submit their application through the <a href=\"https://portal.volkswagenstiftung.de/\">online platform</a>. Applications should include a project description, expenditure plan, and CVs for all PIs. EPFL applicants should include 10% overhead in the budget, as allowed for academic institutions abroad.<br>\r\n<br>\r\n<strong>Deadline:</strong>      06 October 2026, 2pm CET<br>\r\n<br>\r\n<strong>Further information</strong>\r\n\r\n<ul>\r\n\t<li>More information about the program is available <a href=\"https://www.volkswagenstiftung.de/en/funding/funding-offer/next-dual-use-ideas-and-concepts-humanities-and-social-sciences\">here</a></li>\r\n\t<li>An online Q&amp;A session in English is scheduled for <strong>08 Sep 2026 </strong>at 10am</li>\r\n\t<li>For any other questions, please contact the <a href=\"mailto:[email protected]\">Research Office</a></li>\r\n</ul>",
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        {
            "id": 72313,
            "title": "BioAlps Networking Day 2026",
            "slug": "bioalps-networking-day-2026",
            "event_url": "https://memento.epfl.ch/event/bioalps-networking-day-2026",
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            "lang": "en",
            "start_date": "2026-11-19",
            "end_date": "2026-11-19",
            "start_time": "09:00:00",
            "end_time": "19:00:00",
            "description": "<p>The Swiss Health Valley community comes together once a year to connect, exchange ideas and advance life sciences. In 2026, the BioAlps Networking Day will take place in Lausanne on 19 November at the Palais de Beaulieu.<br>\r\n<br>\r\nThe morning programme will showcase the strength and diversity of the Canton of Vaud’s life sciences innovation ecosystem. In the afternoon, discussions will focus on this year’s theme: <strong>Advancing Healthcare Through Digital Innovation</strong>.<br>\r\n<br>\r\nResearchers, entrepreneurs, investors and industry leaders are invited to explore emerging trends, build new partnerships and help shape the future of healthcare.\r\n</p><ul>\r\n\t<li><strong>Early-bird rate:</strong> CHF 120 until 1 September 2026</li>\r\n\t<li><strong>Regular rate:</strong> CHF 150</li>\r\n\t<li>Tickets are non-refundable but may be transferred to another participant until 11 November 2026.</li>\r\n</ul>\r\nFor further information, contact the BioAlps team at <a data-end=\"939\" data-start=\"890\" href=\"mailto:[email protected]\" rel=\"noopener\">[email protected]</a> or call <a data-end=\"984\" data-start=\"948\" href=\"tel:+41225451291\" rel=\"noopener\">+41 22 545 12 91</a>.<br>\r\n<strong>Please note:</strong> 11 November 2026 falls on a Wednesday, not a Friday. The transfer deadline should therefore be verified.<br>\r\n<br>\r\n<strong>BioAlps Networking Day Partners</strong><br>\r\n<a href=\"https://www.chubb.com/\">CHUBB</a> | <a href=\"https://www.csem.ch/Home\" rel=\"noreferrer noopener\" target=\"_blank\">CSEM</a> | <a href=\"https://bioark.ch/\">BIOARK</a> | <a href=\"https://www.biopole.ch/\">BIOPÔLE</a> | <a href=\"https://katzarov.com/\">KATZAROV</a> | <a href=\"http://socorex.com/en/\">SOCOREX</a> | <a href=\"https://www.trbchemedica.ch/fr/\">TRB CHEMEDICA</a><br>\r\n<br>\r\n<strong>Institutional Members</strong><br>\r\n<a href=\"https://www.chuv.ch/fr/chuv-home\" rel=\"noreferrer noopener\" target=\"_blank\">CHUV</a> | <a href=\"https://www.epfl.ch/en/\" rel=\"noreferrer noopener\" target=\"_blank\">EPFL</a> | <a href=\"https://www.hug.ch/en\" rel=\"noreferrer noopener\" target=\"_blank\">HUG</a> | <a href=\"https://www.unige.ch/\" rel=\"noreferrer noopener\" target=\"_blank\">UNIGE</a> |  <a href=\"https://www.unil.ch/index.html\" rel=\"noreferrer noopener\" target=\"_blank\">UNIL</a> | <a href=\"https://www.csem.ch/Home\" rel=\"noreferrer noopener\" target=\"_blank\">CSEM</a> | <a href=\"https://heig-vd.ch/\" rel=\"noreferrer noopener\" target=\"_blank\">HEIG-VD</a> | <a href=\"https://www.hesge.ch/hepia/\" rel=\"noreferrer noopener\" target=\"_blank\">HEPIA</a> | <a href=\"https://www.hevs.ch/en/intro\" rel=\"noreferrer noopener\" target=\"_blank\">HES-SO Valais Wallis</a> | <a href=\"https://www.sib.swiss/\" rel=\"noreferrer noopener\" target=\"_blank\">SIB</a> | <a href=\"https://www.unifr.ch/home/fr/\" rel=\"noreferrer noopener\" target=\"_blank\">UNIFR</a> | <a href=\"https://www.unine.ch/\" rel=\"noreferrer noopener\" target=\"_blank\">UNINE</a> | <a href=\"https://www.idiap.ch/fr\" rel=\"noreferrer noopener\" target=\"_blank\">Idiap</a> | <a href=\"https://www.ecolelasource.ch/\" rel=\"noreferrer noopener\" target=\"_blank\">Institut et Haute Ecole de Santé La Source</a> | <a href=\"https://wysscenter.ch/\">Wyss Center for Bio and Neuroengineering</a> | <a href=\"https://www.heia-fr.ch/\">HEIA-FR | </a><a href=\"https://www.he-arc.ch/domaine/ingenierie/\" rel=\"noopener\" target=\"_blank\">HE-Arc Ingénierie</a>",
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            "creation_date": "2026-08-07T15:54:23",
            "last_modification_date": "2026-08-07T16:06:13",
            "link_label": "Web",
            "link_url": "",
            "canceled": "False",
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                "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api"
            ],
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            "organizer": "<a href=\"https://bioalps.org/\">BioAlps Association</a>",
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                "fr_label": "Sur inscription",
                "en_label": "Registration required"
            },
            "keywords": "",
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            "icalendar_url": "https://memento.epfl.ch/event/export/121384/",
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                "id": 1,
                "code": "CONF",
                "fr_label": "Conférences - Séminaires",
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                "https://memento.epfl.ch/api/v1/mementos/422/?format=api"
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        },
        {
            "id": 72369,
            "title": "Mechanical forces as long-range organizers of cellular physiology",
            "slug": "mechanical-forces-as-long-range-organizers-of-cell",
            "event_url": "https://memento.epfl.ch/event/mechanical-forces-as-long-range-organizers-of-cell",
            "visual_url": "https://memento.epfl.ch/image/33626/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/33626/720x405.jpg",
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            "lang": "en",
            "start_date": "2026-10-16",
            "end_date": "2026-10-16",
            "start_time": "16:00:00",
            "end_time": "16:45:00",
            "description": "<p>In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a contractile back, yet how these GTPases segregate remains unclear. We leverage optogenetics, mechanical perturbations, and modeling to reveal a mechanochemical long-range mutual activation between front and back polarity programs that complements their known local mutual inhibition. Rac-driven protrusions increase membrane tension, triggering mTORC2-dependent Rho activation at the opposite side of the cell. Conversely, Rho-mediated contractility induces cortical-flow regulation of phosphoinositide signaling, promoting distal Rac activation. Our findings demonstrate how the actin cortex and plasma membrane interact as an integrated mechanochemical system for long-range Rac-Rho patterning. Efficient migration also requires polarized organization of the cell interior, with organelle positioning increasingly recognized as a key determinant of cell movement. Yet how this organization is established remains unclear. Building on our mechanochemical framework, we now investigate how actin-generated forces position organelles during migration and how disruption of this intracellular organization contributes to disease.<br>\r\n<br>\r\nWebsite of the De Belly lab: <a href=\"https://cri.utsw.edu/faculty/henry-de-belly/\">https://cri.utsw.edu/faculty/henry-de-belly/</a><br>\r\n<br>\r\nThis is part of the Physics of Living Systems monthly symposium: <a href=\"https://pols.epfl.ch/physics-of-living-systems-seminars/monthly-symposium/\">https://pols.epfl.ch/physics-of-living-systems-seminars/monthly-symposium/</a></p>",
            "image_description": "Dr. Henry De Belly, UTSW",
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            "last_modification_date": "2026-08-19T12:10:32",
            "link_label": "",
            "link_url": "",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "SV 1717",
            "url_place_and_room": "https://plan.epfl.ch/?room==SV%201717",
            "url_online_room": "https://epfl.zoom.us/j/7467019292",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api"
            ],
            "speaker": "Dr. Henry De Belly, UTSW",
            "organizer": "Dr. Juan Manuel García-Arcos, EPFL",
            "contact": "Dr. Juan Manuel García-Arcos, [email protected]",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 2,
                "fr_label": "Public averti",
                "en_label": "Informed public"
            },
            "registration": {
                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Mechanobiology, cell signalling, cell migration, mTORC2, Rho GTPases, cellular organization",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/121471/",
            "category": {
                "id": 1,
                "code": "CONF",
                "fr_label": "Conférences - Séminaires",
                "en_label": "Conferences - Seminars",
                "activated": true
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                "https://memento.epfl.ch/api/v1/mementos/111/?format=api"
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        },
        {
            "id": 72373,
            "title": "Lysosomes at the nexus of cellular quality control and metabolism",
            "slug": "lysosomes-at-the-nexus-of-cellular-quality-control",
            "event_url": "https://memento.epfl.ch/event/lysosomes-at-the-nexus-of-cellular-quality-control",
            "visual_url": "https://memento.epfl.ch/image/33629/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/33629/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/33629/max-size.jpg",
            "lang": "en",
            "start_date": "2026-10-15",
            "end_date": "2026-10-15",
            "start_time": "16:00:00",
            "end_time": "17:00:00",
            "description": "<p>Lysosomes sit at the crossroads of cellular catabolism and quality control, where they must dismantle chemically diverse cargo while preserving their own integrity. I will discuss two discoveries that reveal how lysosomes solve these complementary challenges and how their failure creates disease vulnerabilities. First, I will describe Lysosomal Leucine Aminopeptidase (LyLAP), an enzyme specialized to processively degrade the hydrophobic α-helices of transmembrane proteins. LyLAP is highly expressed in pancreatic ductal adenocarcinoma, where its loss causes hydrophobic peptides to accumulate, compromises lysosomal function, and ultimately leads to cancer cell death, revealing a potential vulnerability in tumors with elevated endocytic activity. I will then describe LASER, a damage-responsive protein assembly that couples lysosomal membrane injury to repair. At its core, the oligomeric protein TFG recognizes LC3/GABARAP proteins conjugated to damaged lysosomes and recruits the ESCRT machinery to restore membrane integrity. Neurodegenerative disease-associated mutations in TFG disrupt this process, linking defective lysosomal repair to human disease. Together, these findings reveal lysosomes as dynamic systems that coordinate cargo degradation with membrane surveillance and repair to maintain cellular homeostasis. <br>\r\n<br>\r\nMore about Dr. Aakriti Jain's lab at UTSW: <a href=\"https://aakritijainlab.com/\">https://aakritijainlab.com/</a></p>",
            "image_description": "Dr. Aakriti Jain",
            "creation_date": "2026-08-19T11:24:24",
            "last_modification_date": "2026-09-21T16:54:33",
            "link_label": "",
            "link_url": "",
            "canceled": "False",
            "cancel_reason": "",
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            "speaker": "Dr. Aakriti Jain, UTSW",
            "organizer": "Dr. Juan Manuel García-Arcos",
            "contact": "Dr. Juan Manuel García-Arcos, [email protected]",
            "is_internal": "False",
            "theme": "",
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                "fr_label": "Public averti",
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            },
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                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "ESCRT, Lysosomal repair, organelle dynamics,  Lysosomal Leucine Aminopeptidase, transmembrane protein degradation",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/121477/",
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                "id": 1,
                "code": "CONF",
                "fr_label": "Conférences - Séminaires",
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