(3d) Metal catalysis for the construction of functionalized aromatic rings
Event details
| Date | 27.04.2026 |
| Hour | 17:15 › 18:00 |
| Speaker | Prof. Marko Hapke, University of Linz |
| Location |
Unil - Génopode B
|
| Category | Conferences - Seminars |
| Event Language | English |
Metal-catalyzed or -mediated methods for the assembly and decoration of (hetero)aromatic systems have become a beacon of synthetic methodology in organic synthesis over the last decades. Transition metal-catalyzed [2+2+2] cycloaddition reactions were part of this development and are now widely recognized for their versatility and atom efficiency. A notable feature of this reaction is its ability to be mediated or catalyzed by a broad range of transition metals.1 Among these, first-row late transition metals, such as nickel and cobalt, were among the earliest to show successful examples of catalytic cyclotrimerizations, exhibiting distinct and unique catalytic properties compared to their heavier counterparts. In particular, the use of CpCo(I) precatalysts for assembling heterocyclic and carbocyclic compounds is highly versatile,2 operating under various conditions and with a steadily expanding substrate scope.3
The development of precatalysts and catalytic systems is, however, still a fruitful field of research and activation under photochemical conditions an active field of research. A recent expansion was the first application of manganese complexes for photo-catalyzed cyclotrimerization reactions, demonstrating simple complexes to be efficient catalysts under irradiation with visible light.4 In particular, the investigation of unusual oxidation states in precatalysts or catalytic cycles can provide novel reactivities and the access to so far rather rarely synthesized compounds, e. g. the synthesis of phosphinines from phosphaalkynes.5
References
[1] A. Roglans, A. Pla-Quintana, M. Sola, Chem. Rev. 2021, 121, 1894-1979.
[2] E. Bednářová, D. Nečas, R. Usman, A. K. Satheeshkumar, R. Gyepes, I. Císařová, M. Hapke, M. Kotora, ChemistryEurope 2025, 3, e202500165.
[3] Overviews: T. Gläsel, B. N. Baumann, M. Hapke, Chem. Rec. 2021, 21, 3727-3745; K. Cen, M. Usman, W. Shen, M. Liu, R. Yang, J. Cai, Org. Biomol. Chem. 2022, 20, 7391-7404.
[4] B. N. Baumann, P. Dam, J. Rabeah, C. Kubis, A. Brückner, H. Jiao, M. Hapke, ACS Catal. 2025, 15, 5718-5730.
[5] T. Gläsel, H. Jiao, M. Hapke, ACS Catal. 2021, 11, 13434-13444.
Practical information
- General public
- Free
Organizer
- Prof. N. Cramer
Contact
- Prof. N. Cramer