Adapting to Mitochondrial Dysfunction via Inter-Organelle Communication
Event details
| Date | 01.02.2016 |
| Hour | 12:15 |
| Speaker | Prof. Cole M. Haynes, Memorial Sloan Kettering Cancer Center, New York, NY (USA) |
| Location | |
| Category | Conferences - Seminars |
DISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
(sandwiches served)
Abstract:
During metazoan development and cell specification, mitochondrial biogenesis is tailored to match the physiologic requirements of individual cell types. Loss of mitochondrial activity, or mitochondrial dysfunction, is tightly linked with a number of seemingly disparate pathologic scenarios including neurodegeneration, cancer, diabetes and bacterial infection.
My laboratory is interested in how cells evaluate mitochondrial function and adapt to survive and ultimately recover from mitochondrial stress. We focus on a mitochondrial-to-nuclear signaling pathway known as the mitochondrial unfolded protein response (UPRmt) that regulates a transcriptional response to repair and recover defective mitochondria. Considerable progress has been made in understanding how cells evaluate mitochondrial function and respond accordingly, however physiologic roles of this stress-activated signal transduction pathway are only emerging.
Here, I’ll discuss a protective role for the UPRmt as a bona fide innate immune response during infection by those bacteria that perturb mitochondrial function. This will be contrasted with a potentially detrimental role for the UPRmt in the propagation of deleterious mitochondrial genomes that may contribute to the mitochondrial deterioration observed in the above-mentioned age-associated diseases.
Bio:
Education:
2003 Ph.D. Cell Biology and Biophysics, University of Missouri Kansas City
1998 B.S. Biology, Truman State University
Research Experience:
2009-present
Associate Member
Cell Biology Program
Memorial Sloan Kettering Cancer Center, New York, NY
Associate Professor, Gerstner Sloan-Kettering Graduate School
Associate Professor, BCMB Program, Weill Cornell Medical College
2004-2009
Postdoctoral Fellow
New York University, Laboratory of David Ron
“Identification and Characterization of UPRmt Signaling Components”
1998-2003
Graduate Student
University of Missouri-Kansas City, Laboratory of Antony Cooper
“Protective adaptations to endoplasmic reticulum dysfunction”
(sandwiches served)
Abstract:
During metazoan development and cell specification, mitochondrial biogenesis is tailored to match the physiologic requirements of individual cell types. Loss of mitochondrial activity, or mitochondrial dysfunction, is tightly linked with a number of seemingly disparate pathologic scenarios including neurodegeneration, cancer, diabetes and bacterial infection.
My laboratory is interested in how cells evaluate mitochondrial function and adapt to survive and ultimately recover from mitochondrial stress. We focus on a mitochondrial-to-nuclear signaling pathway known as the mitochondrial unfolded protein response (UPRmt) that regulates a transcriptional response to repair and recover defective mitochondria. Considerable progress has been made in understanding how cells evaluate mitochondrial function and respond accordingly, however physiologic roles of this stress-activated signal transduction pathway are only emerging.
Here, I’ll discuss a protective role for the UPRmt as a bona fide innate immune response during infection by those bacteria that perturb mitochondrial function. This will be contrasted with a potentially detrimental role for the UPRmt in the propagation of deleterious mitochondrial genomes that may contribute to the mitochondrial deterioration observed in the above-mentioned age-associated diseases.
Bio:
Education:
2003 Ph.D. Cell Biology and Biophysics, University of Missouri Kansas City
1998 B.S. Biology, Truman State University
Research Experience:
2009-present
Associate Member
Cell Biology Program
Memorial Sloan Kettering Cancer Center, New York, NY
Associate Professor, Gerstner Sloan-Kettering Graduate School
Associate Professor, BCMB Program, Weill Cornell Medical College
2004-2009
Postdoctoral Fellow
New York University, Laboratory of David Ron
“Identification and Characterization of UPRmt Signaling Components”
1998-2003
Graduate Student
University of Missouri-Kansas City, Laboratory of Antony Cooper
“Protective adaptations to endoplasmic reticulum dysfunction”
Practical information
- Informed public
- Free