Adult hippocampal neurogenesis: functional implications for memory processing
Event details
| Date | 11.11.2009 |
| Hour | 12:15 |
| Speaker | Dr. Claire Rampon, Centre de Recherches sur la Cognition Animale, Toulouse France. |
| Location |
AI 1 153
|
| Category | Conferences - Seminars |
Host : J.-P. Petit
New neurons are generated throughout adult life in discrete regions of the mammalian brain, including the dentate gyrus of the hippocampus. Some of these newborn neurons become integrated into pre-existing hippocampal circuits, raising the possibility that they may contribute to behaviorally relevant neuronal assemblies. In this aim, we examined whether new neurons born before learning may participate to the retrieval of remotely-acquired spatial memories, we used activity-dependent mapping of the immediate early gene expression and visualized the recruitment of new neurons in a set of controlled water-maze procedures in mice. We established that adult-born neurons constitute a specific pool of cells destined to undergo activity-dependent plastic changes involved in the elaboration of neuronal networks underlying remote spatial memories. Then, we examined whether the inability to acquire and store new information in pathological situation may be related to impaired adult hippocampal neurogenesis. We used transgenic mice models of Alzheimer’s disease to address this question.
Practical information
- General public
- Free