Advancing Late-Stage Functionalization: Syngenta's High-Throughput Approaches to C-H Borylation and Thianthrenation

This lecture will showcase Syngenta's state-of-the-art Chemistry Automation platform, highlighting its role in advancing late-stage functionalization research.
We will explore the “standardized linchpin approach” for expanding practical utility of C-H borylation and C-H thianthrenation, miniaturization techniques, regiodivergent protocols, and solutions to the substrate-dependent condition identification challenge.
Applications to diverse bioactive compounds, including pharmaceuticals and agrochemicals, will demonstrate how late-stage functionalization may help to accelerate research.