Applying Multi-Organ-on-a-Chip Technologies for Predictive Substance Testing
Event details
| Date | 15.05.2017 |
| Hour | 12:15 › 13:30 |
| Speaker | Dr. Ing. Reyk HORLAND, TissUse GmBH, Berlin (D) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Current in vitro and animal tests do not reliable predict the human responses to drugs or substances because they are failing to emulate the organ complexity of the human body, leading to high attrition rates in clinical studies. For example, absorption, distribution, metabolism and excretion (ADME) are key factors for predicting safety and efficacy of therapeutic candidates. However, these systemic effects are ignored in most in vitro tests. In order to emulate the physiological relevant in vivo crosstalk with the ability to perform systemic substance testing, we have developed a universal Multi‑Organ-Chip platform for long-term culture of human organ equivalents interconnected within a common capillary microfluidic network. The on-chip micro-pump ensures stable long-term circulation of media through the tissue culture compartments at variable flow rates, adjustable to physiological mechanical stresses of the respective tissues. This talk will present examples of current organ combinations and how the advanced knowledge and experience acquired will eventually enable the development of a Human-on-a-chip system. In addition, the question of how to qualify and validate these systems will be addressed.
Bio:
Since 2010 Reyk Horland is actively involved in the development of TissUse GmBH’s Multi-Organ-Chip platform for culture analysis of drug candidates, cosmetics, chemicals and consumer products. He currently holds the position of Head (VP) of Business Development at TissUse.
Prior to TissUse Reyk studied Biotechnology at the Technische Universität Berlin and specialized in Medical Biotechnology. During his academic career he was involved in various tissue engineering programs, all with a focus on commercialisation of the respective products.
Abstract:
Current in vitro and animal tests do not reliable predict the human responses to drugs or substances because they are failing to emulate the organ complexity of the human body, leading to high attrition rates in clinical studies. For example, absorption, distribution, metabolism and excretion (ADME) are key factors for predicting safety and efficacy of therapeutic candidates. However, these systemic effects are ignored in most in vitro tests. In order to emulate the physiological relevant in vivo crosstalk with the ability to perform systemic substance testing, we have developed a universal Multi‑Organ-Chip platform for long-term culture of human organ equivalents interconnected within a common capillary microfluidic network. The on-chip micro-pump ensures stable long-term circulation of media through the tissue culture compartments at variable flow rates, adjustable to physiological mechanical stresses of the respective tissues. This talk will present examples of current organ combinations and how the advanced knowledge and experience acquired will eventually enable the development of a Human-on-a-chip system. In addition, the question of how to qualify and validate these systems will be addressed.
Bio:
Since 2010 Reyk Horland is actively involved in the development of TissUse GmBH’s Multi-Organ-Chip platform for culture analysis of drug candidates, cosmetics, chemicals and consumer products. He currently holds the position of Head (VP) of Business Development at TissUse.
Prior to TissUse Reyk studied Biotechnology at the Technische Universität Berlin and specialized in Medical Biotechnology. During his academic career he was involved in various tissue engineering programs, all with a focus on commercialisation of the respective products.
Practical information
- Informed public
- Free