BMI Progress Reports 2020 // Prof. McCabe's Lab - Jamshid Asadzadeh : Glutamate receptors interact with transcription factors to regulate synaptic scaling
Event details
Date | 09.12.2020 |
Hour | 13:15 › 14:00 |
Speaker | Jamshid Asadzadeh, Laboratory of Neural Genetics and Disease, BMI |
Location | |
Category | Conferences - Seminars |
Synaptic scaling, where postsynaptic receptor levels or composition are altered in response to changes in network activity, is an important adaptive mechanism to maintain circuit homeostasis. Here we describe a novel scaling activity of glutamate receptors in Drosophila motor synapses. Surprisingly, we demonstrate that regulation of this scaling process employs direct activity-dependent molecular interaction of glutamate receptors with postsynaptic transcription factors. Our results reveal a novel mechanism for activity-dependent gene regulation, where changes in synaptic activity can immediately influence neuronal transcription factor function, without the requirement for intermediary signal transduction cascades.
Practical information
- Informed public
- Free
Organizer
- Brain Mind Institute