Conferences - Seminars

21MAR
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  Wednesday 21 March 2018 12:15 - 13:15 SV 1717

BMI SEMINAR // Basal forebrain circuits contribute to default mode network regulation

By Gregor Rainer, Visual Cognition Laboratory, Dept. of Medicine / Physiology, University of Fribourg, Switzerland


The default mode network (DMN) is a collection of cortical brain regions that is active during task-off, internally directed brain states associated with quiet wakefulness.  I will summarize recent evidence obtained in the rat suggesting that the basal forebrain may represent a hitherto undiscovered subcortical node of the default mode network.  I will discuss potential roles of distininct basal forebrain projections in DMN regulation, with particular reference to GABAergic and neuropeptidergic systems.  These findings may represent a novel way to influence DMN activity, which may have an impact on brain disorders that bear a relation to the DMN such as depression and epilepsy.
 

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