Conferences - Seminars
BMI SEMINAR // Stress exacerbation of cardiometabolic and aging-associated diseases
By Alessandro Bartolomucci, Dept. of Integrative Biology and Physiology (IBP), Center for Neurobehavioral Development, University of Minnesota, Minneapolis, USA
Chronic Stress and low socioeconomic status in humans confer increased vulnerability to morbidity and mortality. However, this association is not mechanistically understood nor has its causation been explored for the most common cardiovascular and metabolic disease affecting humans. We will discuss separate studies from our laboratory collectively demonstrating: 1) how chronic stress modulates the vulnerability or resilience to obesity via regulating energy intake and energy expenditure and via activation of the brown adipose tissue (BAT); 2) how chronic stress exacerbates cardiovascular diseases, particularly in already vulnerable individuals; and 3) how lifelong chronic stress shortens lifespan and increase the risk of cardiovascular and neurodegenerative disorders in subordinate mice. Collectively, our data highlight a conserved role for social stress and low social status on shortening lifespan and increasing the risk of cardiometabolic diseases in mammals and identify potential mechanistic links for this complex phenomenon.
Organization SV BMI - Host : C. Sandi
Accessibility Informed public