Cell Size and Ploidy: From Single Cells to the Physiology of Vertebrate Embryos


Event details

Date 28.02.2024
Hour 09:1510:15
Speaker Clotilde Cadart, Ph.D., Group Leader, Institut Cochin, Paris (FR)
Location Online
Category Conferences - Seminars
Event Language English
Cell size correlates positively with DNA content both within species as a function of ploidy (i.e. genome copy number) and across species as a function of genome size yet the impacts on cellular and organismal physiology are poorly understood. Xenopus frogs are ideal for exploring this question since their genome size varies widely across species and ploidy can be manipulated within a species. During my postdoctoral work (UC Berkeley, Pr. Heald’s lab), I found that triploid X. laevis and X. borealis tadpoles of identical mass to diploids consist of fewer, larger cells and consume oxygen at a lower rate. Comparison with a dodecaploid species, X. longipes, revealed that metabolic differences emerged during development only when cell size began to scale with genome size. These findings suggest that genome size affects metabolism through changes in cell size and that less energy is required to sustain larger cells within the same multicellular organism. In future work, my research will combine experiments on single cells and Xenopus embryos to understand how cell and genome size/ploidy affect the physiology and evolution of multicellular organisms.

2024 - Present    Junior Group Leader, Institut Cochin, Paris (FR)
2018 - 2023    Postdoctoral Researcher, University of California, Berkeley (USA)
2013 - 2018    Ph.D., Institut Curie, Paris (FR)
2012 - 2013    Master's degree, Biophysics, Université Paris Cité, Paris (FR)
2009 - 2012    study of Medicine, Université Claude Bernard Lyon 1 (FR)

Zoom link for attending remotely, if needed: https://epfl.zoom.us/j/67478649238

Practical information

  • Informed public
  • Free