Changing Neighbours: Bone Marrow Remodeling during Ageing and Age-Related Myeloproliferative Diseases
Event details
| Date | 17.06.2019 |
| Hour | 12:15 |
| Speaker | Dr. Simón Méndez-Ferrer Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, and NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge (UK) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
(sandwiches served)
Abstract:
Haematopoietic stem cells residing in the bone marrow accumulate during ageing but are functionally impaired. However, the role of haematopoietic-stem-cell-intrinsic and -extrinsic ageing mechanisms remains debated. Myeloid malignancies are more frequent in the elderly, but whether changes in the aged haematopoietic stem cells and/or their microenvironment predispose to these malignancies remains unclear. In the first part of the talk, unpublished evidence will be presented indicating that the bone marrow microenvironment promotes haematopoietic ageing, both during physiology and in premature, pathological haematopoietic ageing, which can be improved by targeting the microenvironment. In the second part of the talk, preliminary data will be discussed supporting the concept that the interaction of mutant haematopoietic stem cells with different bone marrow niches can influence the progression of myeloid malignancies driven by the same oncogenic pathway. Together, these results endorse the microenvironment as a complementary therapeutic target in age-related myeloid malignancies.
Bio:
Méndez-Ferrer is currently Reader at the University of Cambridge, a PI of NHS-Blood and Transplant and the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute (UK). He received his B.S. degree in Seville (Spain) from 1999 and a Ph.D. degree in the same city from 2004. He did his postdoctoral work at the Icahn School of Medicine at Mount Sinai, New York. Méndez-Ferrer has discovered a connection with bone marrow, the brain and other systemic signals which controls the behaviour of blood stem cells. His research has contributed to the dissection of the "niches" in which stem cells reside and to the understanding of the role of these niches in the development of myeloproliferative diseases.
(sandwiches served)
Abstract:
Haematopoietic stem cells residing in the bone marrow accumulate during ageing but are functionally impaired. However, the role of haematopoietic-stem-cell-intrinsic and -extrinsic ageing mechanisms remains debated. Myeloid malignancies are more frequent in the elderly, but whether changes in the aged haematopoietic stem cells and/or their microenvironment predispose to these malignancies remains unclear. In the first part of the talk, unpublished evidence will be presented indicating that the bone marrow microenvironment promotes haematopoietic ageing, both during physiology and in premature, pathological haematopoietic ageing, which can be improved by targeting the microenvironment. In the second part of the talk, preliminary data will be discussed supporting the concept that the interaction of mutant haematopoietic stem cells with different bone marrow niches can influence the progression of myeloid malignancies driven by the same oncogenic pathway. Together, these results endorse the microenvironment as a complementary therapeutic target in age-related myeloid malignancies.
Bio:
Méndez-Ferrer is currently Reader at the University of Cambridge, a PI of NHS-Blood and Transplant and the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute (UK). He received his B.S. degree in Seville (Spain) from 1999 and a Ph.D. degree in the same city from 2004. He did his postdoctoral work at the Icahn School of Medicine at Mount Sinai, New York. Méndez-Ferrer has discovered a connection with bone marrow, the brain and other systemic signals which controls the behaviour of blood stem cells. His research has contributed to the dissection of the "niches" in which stem cells reside and to the understanding of the role of these niches in the development of myeloproliferative diseases.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson