Chemical Dynamics in Developing Tissues
Event details
| Date | 29.01.2018 |
| Hour | 12:15 |
| Speaker | Yogesh Goyal, Ph.D., University of Pennsylvania, Philadelphia, PA (USA) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Despite its inherent complexity, animal development is a remarkably robust process. In some cases, however, perturbations to developmental processes can result in abnormal outcomes. I am interested in understanding the origins of such abnormalities, which are often a result of alterations in the underlying chemical processes. Specifically, I focus on abnormalities caused by mutations in the Ras signaling network, which controls a wide range of processes in adult and developing tissues. We have developed quantitative frameworks with spatiotemporal resolution to monitor molecular and morphological effects of perturbations in developing fly embryos. Using these tools, we found that intrinsically active mutations can both increase and reduce the levels of Ras pathway output, a surprising, yet highly significant result. Our discovery has broad implications for the basic understanding of a large class of developmental abnormalities and urges caution when it comes to considering their pharmacological treatments. In parallel, we have developed novel optogenetic-based tools that can be used to probe the differential contributions of dose, duration, and spatial range of Ras activity on animal development. Together, our multiscale approach can be used to dissect the underlying properties of chemical networks in developmental systems.
Bio:
Yogesh Goyal attended Indian Institute of Technology (IIT) Gandhinagar in India and received his undergraduate in Chemical Engineering. He then joined Princeton University as a graduate student (2012-2017) where he was co-advised by Stanislav Shvartsman and Trudi Schüpbach. At Princeton, Yogesh was affiliated with the department of Chemical and Biological Engineering and the Lewis-Sigler Institute for Integrative Genomics. He just started his postdoc with Arjun Raj in Bioengineering at the University of Pennsylvania. Yogesh is broadly interested in developing quantitative experimental and computational frameworks to understand developmental and invasive systems.
Abstract:
Despite its inherent complexity, animal development is a remarkably robust process. In some cases, however, perturbations to developmental processes can result in abnormal outcomes. I am interested in understanding the origins of such abnormalities, which are often a result of alterations in the underlying chemical processes. Specifically, I focus on abnormalities caused by mutations in the Ras signaling network, which controls a wide range of processes in adult and developing tissues. We have developed quantitative frameworks with spatiotemporal resolution to monitor molecular and morphological effects of perturbations in developing fly embryos. Using these tools, we found that intrinsically active mutations can both increase and reduce the levels of Ras pathway output, a surprising, yet highly significant result. Our discovery has broad implications for the basic understanding of a large class of developmental abnormalities and urges caution when it comes to considering their pharmacological treatments. In parallel, we have developed novel optogenetic-based tools that can be used to probe the differential contributions of dose, duration, and spatial range of Ras activity on animal development. Together, our multiscale approach can be used to dissect the underlying properties of chemical networks in developmental systems.
Bio:
Yogesh Goyal attended Indian Institute of Technology (IIT) Gandhinagar in India and received his undergraduate in Chemical Engineering. He then joined Princeton University as a graduate student (2012-2017) where he was co-advised by Stanislav Shvartsman and Trudi Schüpbach. At Princeton, Yogesh was affiliated with the department of Chemical and Biological Engineering and the Lewis-Sigler Institute for Integrative Genomics. He just started his postdoc with Arjun Raj in Bioengineering at the University of Pennsylvania. Yogesh is broadly interested in developing quantitative experimental and computational frameworks to understand developmental and invasive systems.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)