Cortical and subcortical mechanisms of stress adaptation and pathology
Event details
| Date | 21.03.2017 |
| Hour | 11:30 › 12:30 |
| Speaker | Sriparna Ghosal, Ph.D., Department of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT (USA) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
The organismal stress response is an integrated physiological and behavioral response to actual or perceived threat to homeostasis. The brain plays a central role in orchestrating these stress responses via many interacting circuits in the forebrain, hypothalamus and brainstem. This seminar will discuss prominent hypothalamic mechanisms that integrate distinct brainstem monosynaptic inputs required for the global regulation of stress responses across multiple effector systems. In addition, the seminar will present how reorganization of prefrontal cortical stress-control circuitry in the chronically stressed brain contributes to depression, and how this relates to rapid acting antidepressant such as the NMDA receptor antagonist ketamine or scopolamine, a non-selective muscarinic acetylcholine receptor antagonist. Collectively, these studies demonstrate that stress-induced imbalances among cortical and subcortical circuits play a casual role in the development of maladaptive stress reactions that can culminate in affective diseases.
Bio:
Jun 2015 – Present: Yale School of Medicine, Postdoctoral Fellow
Jul 2010 – May 2015: University of Cincinnati Graduate student
IMPORTANT:
All external participants have to pass through SV Reception/Welcome Desk to be able to access room AI 1153. Contact person to call at arrival at SV Reception Desk: Administrative Assistant: 39522 / Kristina Schoonjans: 31891.
Abstract:
The organismal stress response is an integrated physiological and behavioral response to actual or perceived threat to homeostasis. The brain plays a central role in orchestrating these stress responses via many interacting circuits in the forebrain, hypothalamus and brainstem. This seminar will discuss prominent hypothalamic mechanisms that integrate distinct brainstem monosynaptic inputs required for the global regulation of stress responses across multiple effector systems. In addition, the seminar will present how reorganization of prefrontal cortical stress-control circuitry in the chronically stressed brain contributes to depression, and how this relates to rapid acting antidepressant such as the NMDA receptor antagonist ketamine or scopolamine, a non-selective muscarinic acetylcholine receptor antagonist. Collectively, these studies demonstrate that stress-induced imbalances among cortical and subcortical circuits play a casual role in the development of maladaptive stress reactions that can culminate in affective diseases.
Bio:
Jun 2015 – Present: Yale School of Medicine, Postdoctoral Fellow
Jul 2010 – May 2015: University of Cincinnati Graduate student
IMPORTANT:
All external participants have to pass through SV Reception/Welcome Desk to be able to access room AI 1153. Contact person to call at arrival at SV Reception Desk: Administrative Assistant: 39522 / Kristina Schoonjans: 31891.
Links
Practical information
- Informed public
- Free
Organizer
- Prof. Kristina Schoonjans on behalf of the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA)
Contact
- Prof. Kristina Schoonjans for the LIMNA Alliance