EPFL BioE Talks SERIES "Single-Molecule Detection by Membrane Nanopores"


Event details

Date 25.10.2021
Hour 16:0017:00
Speaker Chan Cao, Ph.D., School of Life Sciences, EPFL, Lausanne (CH)
Location Online
Category Conferences - Seminars
Event Language English

Nanopore is a powerful single-molecule approach that allows the characterization of molecules of interest in a label-free, fast, cheap, and real-time way with sub-angstrom resolution and without any amplification in aqueous solutions. Membrane nanopore has been successfully applied for sequencing long fragments of DNA and shown great potential for single-molecule proteomics applications and next-generation information storage. I will first present our work aimed at tuning the structure of membrane nanopores towards a higher sensing resolution. By integrating experiments with molecular dynamics simulations, we have systematically characterized the sensing region of the pore, and then explored the structure-function relationship between the pore structure and its molecular sensing properties. Second, we utilized the engineered pore to decode digital information stored in tailored macromolecules with a single-bit resolution, which provides an alternative reading and writing strategy for molecular digital data storage.

Dr. Chan Cao received her PhD in Analytical Chemistry from ECUST (Shanghai, China) in 2017, after which she worked as a postdoc fellow at EPFL. Chan currently is an SNSF PRIMA fellow in the EPFL School of Life Sciences (SV). Her research interests center around the development and application of advanced nanotechnology to study the properties, structure, dynamic and function of biomolecules of interest at atomic and molecular level. In particular, she is specialized on nanopore single-molecule technology, including engineering and design of biological nanopores, detection of protein biomarkers, single-molecule protein sequencing, and molecular digital data storage. Chan has received the Annual Jeffrey Hubbell and Melody Swartz Young Bioengineer award in 2020, Synapsis Career Development award in 2020, Shanghai Mayer award in 2017 and American Chemical Society Outstanding Graduate Student Research award in 2016.

As a consequence of the ongoing Covid-19 pandemic, in-person attendance of this seminar is subjected to some constraints:
  • Maximum number of participants is limited to 80 (2/3 of room SV1717's nominal capacity): first come, first served!
  • Valid COVID certificate and ID, required to enter the meeting room, will be checked at the entrance
  • Face masks are mandatory for everyone in the seminar room (excepted the speaker while presenting).
Thank you warmly for your understanding!

Alternatively, the seminar can also be followed via Zoom web-streaming:
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks

Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IF you are not attending in-person in the room, please make sure to
  1. send D. Reinhard a note before noon on seminar day, informing that you plan to attend the talk online, and
  2. be signed in on Zoom with a recognizable user name (not a pseudonym making it difficult or impossible to be identified).
Students attending the seminar in-person should collect a confirmation signature after the talk - please print your own signature sheet beforehand (71 kB pdf available for download here).

Practical information

  • Informed public
  • Registration required