EPFL BioE Talks SERIES "Small Changes – Big Impact? How Lipid Diversity Affects Signaling"
Event details
| Date | 23.05.2022 |
| Hour | 16:00 › 17:00 |
| Speaker | Milena Schuhmacher, Ph.D., Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden (D) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
WEEKLY EPFL BIOE TALKS SERIES
Abstract:
Lipids are essential for numerous cellular functions and signaling processes. However, they are understudied compared to other biological molecules such as proteins mainly due to a lack of appropriate methodology. Compared to proteins, it is very difficult to introduce perturbations such as concentration changes and it is further very challenging to visualize lipids especially in a cellular context. This has mainly to do with both the size and also the chemical diversity of lipids. Chemical biology approaches such as the introduction of photolabile moieties, photocrosslinking- and click chemistry-groups offer the possibility to fill this methodological gap and in particular to address biological questions on the level of individual lipid species. Using diacylglycerols as an exemplary lipid class, we employed such an approach to understand how individual lipid species can exert a specific function in the cell and how minor structural differences can influence lipid dynamics in the plasma membrane.
Bio:
2020 to present | Postdoctoral researcher (biological chemistry) , Max Planck Institute of Molecular Cell Biology and Genetics: Dresden (D)
2015 to 2020 | PhD (chemical biology), Max Planck Institute of Molecular Cell Biology and Genetics: Dresden (D)
2012 to 2015 | Master (Chemistry), Ruprecht Karls Universität Heidelberg (D)
2008 to 2012 | Bachelor (Chemistry), Ruprecht Karls Universität Heidelberg (D).
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
Please make sure to
Abstract:
Lipids are essential for numerous cellular functions and signaling processes. However, they are understudied compared to other biological molecules such as proteins mainly due to a lack of appropriate methodology. Compared to proteins, it is very difficult to introduce perturbations such as concentration changes and it is further very challenging to visualize lipids especially in a cellular context. This has mainly to do with both the size and also the chemical diversity of lipids. Chemical biology approaches such as the introduction of photolabile moieties, photocrosslinking- and click chemistry-groups offer the possibility to fill this methodological gap and in particular to address biological questions on the level of individual lipid species. Using diacylglycerols as an exemplary lipid class, we employed such an approach to understand how individual lipid species can exert a specific function in the cell and how minor structural differences can influence lipid dynamics in the plasma membrane.
Bio:
2020 to present | Postdoctoral researcher (biological chemistry) , Max Planck Institute of Molecular Cell Biology and Genetics: Dresden (D)
2015 to 2020 | PhD (chemical biology), Max Planck Institute of Molecular Cell Biology and Genetics: Dresden (D)
2012 to 2015 | Master (Chemistry), Ruprecht Karls Universität Heidelberg (D)
2008 to 2012 | Bachelor (Chemistry), Ruprecht Karls Universität Heidelberg (D).
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
Please make sure to
- send D. Reinhard a note before noon on seminar day, informing that you plan to attend the talk online, and
- be signed in on Zoom with a recognizable user name (not a pseudonym making it difficult or impossible to be identified).
Practical information
- Informed public
- Registration required
Organizer
- Dr. Gioele La Manno, EPFL
Contact
- Institute of Bioengineering (IBI), Dietrich REINHARD