From Stripes to Blood Flow: Decoding Cell Fate Emergence in the Lateral Plate Mesoderm
Event details
| Date | 19.04.2018 |
| Hour | 15:00 › 16:00 |
| Speaker | Prof. Christian Mosimann, University of Zurich (CH) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
In vertebrates, cardiovascular progenitors arise along with kidney, smooth muscle, and limb skeleton lineages from lateral plate mesoderm (LPM). How LPM is specified and what molecular features connect its distinct cell fates remain vaguely defined, in part due to the LPM’s dynamic architecture. By combining live imaging, cis-regulatory element analysis, and cross-species reporter assays centered on the zebrafish, we are charting the emergence of the LPM and trace its control back to an evolutionarily conserved regulatory program. These findings provide a paradigm for the origins of essential parts in the vertebrate body plan and establish a genetic basis for the programming of cardiovascular lineages in vitro.
Bio:
Abstract:
In vertebrates, cardiovascular progenitors arise along with kidney, smooth muscle, and limb skeleton lineages from lateral plate mesoderm (LPM). How LPM is specified and what molecular features connect its distinct cell fates remain vaguely defined, in part due to the LPM’s dynamic architecture. By combining live imaging, cis-regulatory element analysis, and cross-species reporter assays centered on the zebrafish, we are charting the emergence of the LPM and trace its control back to an evolutionarily conserved regulatory program. These findings provide a paradigm for the origins of essential parts in the vertebrate body plan and establish a genetic basis for the programming of cardiovascular lineages in vitro.
Bio:
- since Spring 2013:
SNSF/SNF Assistant Professor, Institute of Molecular Life Sciences (IMLS), University of Zurich (UZH); Zürich, Switzerland. - 2008-2013:
Postdoctoral research fellow with Leonard Zon, MD, HHMI/Boston Children's Hospital/Harvard Medical School; Boston, USA.
EMBO Long-term Fellowship (2008-2009).
HFSP Long-term Fellowship (2009-2012).
SNSF/SNF Advanced Researcher Fellowship (2012-2013).
NIH NI-DDK K99/R00 (2012). - 2004-2008:
Ph. D. in Molecular Biology, with Konrad Basler, PhD, Instute of Molecular Biology, UZH; Zürich, Switzerland. - 1999-2003:
Diploma in Molecular Biology, Biochemical Immunology, Chemical Physics, UZH; Zürich, Switzerland.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)