Function and evolutionary origin of bacterial effectors subverting host cell signaling
Event details
| Date | 29.05.2015 |
| Hour | 11:00 › 12:00 |
| Speaker | Dr. Christoph Dehio, Biozentrum, University of Basel, Switzerland |
| Location |
SV 1717a
|
| Category | Conferences - Seminars |
Pathogenic bacteria typically use dedicated protein secretion machineries to translocate bacterial effector proteins into host cells in order to manipulate cellular signaling pathways to their benefit. Pathogens of the genus Bartonella that cause chronic blood infections in a wide range of mammals have provided insights how such trans-kingdom protein transfer systems and their translocated effectors have evolved from preexisting bacterial structures, and how they target specific host cellular signaling processes. The bartonellae employ for effector translocation so called type IV secretion machineries that evolved from the bacterial conjugation machinery. Their diverse translocated effector sets evolved from a single bacterial toxin-antitoxin module by multiple rounds of gene duplication and diversification. The effectors display multi-domain architectures that are composed of only three basic domain types that are highly versatile in function. I will use a striking example of parallel evolution to illustrate emergence of convergent effectors sets in separate Bartonella lineages. Moreover, I will provide examples of how individual effectors interfere with important host cell signaling processes such as those controlling innate immune signaling, cell death and cytoskeletal rearrangements.
Practical information
- Informed public
- Free
Organizer
- Life Science Seminar Series