How to Make a Blood Vessel Sprout
Event details
| Date | 29.09.2014 |
| Hour | 14:00 › 15:00 |
| Speaker | Prof. Nathan Lawson, University of Massachusetts Medical School, Worcester, MA (USA) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
The formation of new blood vessels from pre-existing ones, a process known as angiogenesis, is essential for embryonic growth and is associated with a number of pathological settings. Given the major benefits of the zebrafish – namely, rapidly developing transparent embryos and genetic amenability – this model system has enabled detailed analysis and genetic dissection of morphogenetic processes. For more than a decade, we have taken advantage of the zebrafish to reveal new insights into developmental angiogenesis. In this regard, we have applied forward genetic screens, along with high content imaging, and other analyses to identify pathways important for the formation of new blood vessels. At the same time, we have developed and applied new tools to facilitate transgenesis and enable targeted gene disruption in zebrafish. This seminar will provide an overview of our past work in these areas and highlight where the zebrafish is poised to make additional contributions to the study of vascular development and disease.
Bio:
Nathan Lawson arrived at UMass in 2002 after finishing postdoctoral work in Brant Weinstein's lab at the NIH. Prior to that, he received his Ph.D. from Yale University in 1999.
Abstract:
The formation of new blood vessels from pre-existing ones, a process known as angiogenesis, is essential for embryonic growth and is associated with a number of pathological settings. Given the major benefits of the zebrafish – namely, rapidly developing transparent embryos and genetic amenability – this model system has enabled detailed analysis and genetic dissection of morphogenetic processes. For more than a decade, we have taken advantage of the zebrafish to reveal new insights into developmental angiogenesis. In this regard, we have applied forward genetic screens, along with high content imaging, and other analyses to identify pathways important for the formation of new blood vessels. At the same time, we have developed and applied new tools to facilitate transgenesis and enable targeted gene disruption in zebrafish. This seminar will provide an overview of our past work in these areas and highlight where the zebrafish is poised to make additional contributions to the study of vascular development and disease.
Bio:
Nathan Lawson arrived at UMass in 2002 after finishing postdoctoral work in Brant Weinstein's lab at the NIH. Prior to that, he received his Ph.D. from Yale University in 1999.
Practical information
- Informed public
- Free