IDOL-izing Cholesterol
Event details
| Date | 01.04.2014 |
| Hour | 10:00 › 11:00 |
| Speaker | Vincenzo Sorrentino, Ph.D., University of Amsterdam (NL) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Elevated levels of plasma Low-Density-Lipoprotein cholesterol (LDL-C) represent a major risk factor for development of atherosclerosis. Owing to its ability to promote LDL uptake into cells the LDL receptor (LDLR) is an important determinant of plasma LDL level and is a target for human cardiovascular therapy. The LDLR abundance is tightly regulated both on transcriptional and post-transcriptional level, and recently the E3-ubiquitin ligase IDOL was identified as a novel modulator of the LDLR. Acting as an E3 ligase, IDOL supports ubiquitylation of the LDLR on its protruding intracellular tail thereby targeting it for lysosomal degradation, therefore impairing the uptake of LDL in the cell. My talk will focus on the work I carried out on the characterization, regulation and functional implications of this novel regulatory pathway in cholesterol homeostasis.
Bio:
2003 – 2009
Master student, Biotechnological Sciences, Università degli Studi di Napoli 'Federico II' (Italy)
2009 – 2010
Master student, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam (NL)
2010 – Present
PhD student, Academic Medical Center (AMC), University of Amsterdam (NL)
Abstract:
Elevated levels of plasma Low-Density-Lipoprotein cholesterol (LDL-C) represent a major risk factor for development of atherosclerosis. Owing to its ability to promote LDL uptake into cells the LDL receptor (LDLR) is an important determinant of plasma LDL level and is a target for human cardiovascular therapy. The LDLR abundance is tightly regulated both on transcriptional and post-transcriptional level, and recently the E3-ubiquitin ligase IDOL was identified as a novel modulator of the LDLR. Acting as an E3 ligase, IDOL supports ubiquitylation of the LDLR on its protruding intracellular tail thereby targeting it for lysosomal degradation, therefore impairing the uptake of LDL in the cell. My talk will focus on the work I carried out on the characterization, regulation and functional implications of this novel regulatory pathway in cholesterol homeostasis.
Bio:
2003 – 2009
Master student, Biotechnological Sciences, Università degli Studi di Napoli 'Federico II' (Italy)
2009 – 2010
Master student, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam (NL)
2010 – Present
PhD student, Academic Medical Center (AMC), University of Amsterdam (NL)
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx (for the LIMNA Alliance)
Contact
- Johan Auwerx
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(*) IMPORTANT NOTICE : All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call at arrival at SV Reception Desk: Johan Auwerx 30951 / Administrative Assistant: 39522.