Imaging cell signaling by high spatial-temporal resolution fluorescence spectroscopy - Paolo Annibale
Event details
| Date | 04.12.2020 |
| Hour | 14:15 › 15:00 |
| Speaker |
Paolo Annibale I am a cell biologist and biophysicist with over ten years of experience as a research microscopist, first using scanning probe methods, then fluorescence fluctuations and superresolution techniques. This expertise builds on top of a training in solid state physics, molecular electronics and semiconducting thin films matured working in Italy, Switzerland the US and now Germany. I am currently leading a small team in Berlin researching fundamental molecular mechanisms modulating G protein-coupled Receptors (GPCR) signaling and the underlying pharmacology, within the context of a grant of the German Research Foundation. |
| Location | Online |
| Category | Conferences - Seminars |
Cell signaling, in particular that mediated by G Protein-Coupled Receptors (GPCRs), entails multiple levels, starting from ligand binding, proceeding with receptor activation, coupling to downstream signaling partners and finally generation of second messenger molecules. Each of these steps, can be finely modulated by the local environment that the key signaling proteins are experiencing within the cell. In multiple instances, this subcellular modulation is responsible for surprisingly diverse responses to apparently similar stimuli. The molecular mechanisms responsible for this heterogeneous subcellular response can be visualized and investigated by a toolbox of high spatial and temporal resolution fluorescence spectroscopy methods, which I will introduce in this talk together with relevant examples.
Practical information
- General public
- Free