IMX Seminar Series - Adaptive polymer assemblies with life-like features

Compartmentalization is generally regarded as one of the key prerequisites for life. To better understand the role of compartmentalization, there is a clear need for model systems that can be adapted in a highly controlled fashion, and in which life-like properties can be installed. Polymer-based compartments are robust and chemically versatile, and as such are a useful platform for the development of life-like compartments. In this lecture we discuss polymer vesicles, which are modified in shape and function to show life-like features as catalytic activity, motility and transient behavior.  A second platform technology is based on complex coacervates, stabilized by a biodegradable block copolymer. The specific feature of the polymer membrane is its semipermeable character.  Enzymes inside the protocell can therefore still be reached by their substrates, and small molecule products can be excreted. This allows protocell communication with this robust synthetic platform.