Interareal interactions in the sensorimotor network: from mechanisms to interventions
Event details
| Date | 04.02.2015 |
| Hour | 12:00 › 13:00 |
| Speaker | Prof Friedhelm C. Hummel, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. |
| Location | |
| Category | Conferences - Seminars |
The integration of individuals into modern societies relies on their ability to dynamically adjust to a fast changing environment. This holds especially true during advancing age, paralleled by a decline in cognitive functions and the ability to acquire new skills, and after a focal brain lesion, such as a stroke, both impacting significantly integration in social and professional life. For example, complete motor recovery occurs in less than 15% of stroke patients. Residual deficits of the hand function are a key impediment for reintegration in daily social and professional life. In the view of an aging society and 270.000 strokes per year in e.g., Germany, predicted to increase up to 450.000/year in 2050, it is of great importance to develop novel interventional strategies to enhance functional recovery and age-declined cognitive functions to warrant best integration and independence in society. To achieve these goals it is crucial to better understand adaptive and mal-adaptive changes of the cerebral networks after a stroke and during healthy aging.
Within the present talk an overview of current findings regarding (a) changes of interareal interactions and connectivity of network hubs of the sensorimotor network determined by a multimodal systems neuroscience approach including paired-pulse TMS, EEG, structural and functional MR-imaging, (b) modulation of hubs of the sensorimotor network by non-invasive brain stimulation and its effects on motor functions, including executive control and learning, and (c) its underlying mechanisms will be provided. At the end, an outlook on promising future directions such as prediction of recovery, patient stratification for specific treatments, or modelling approaches will be discussed.
Bio: Friedhelm C. Hummel serves as the Vice Director of the Department of Neurology and the Co-Chairman of the University Sleep Laboratory of the University Medical Center Hamburg-Eppendorf, Hamburg. He is the head of the BrainImaging and NeuroStimulation (BINS) Laboratory, and a leading expert in functional regeneration after stroke, mechanisms of healthy aging, interventional neuroscience and neuroplasticity. To this end, he is using a multimodal systems neuroscience research approach in humans, including behavioral tasks focused on executive control and learning, non-invasive brain stimulation, functional and structural imaging and modelling. Since 2013, he is holding a guest professorship at the Favoloro University, Buenos Aires, Argentina. He received grants from various funding organizations, including the German
Research Foundation (DFG), the German Ministry for Research and Education (BMBF) and the Humboldt-Foundation (AvH). So far, he published more than 100 research papers in excellent international peer-reviewed journals and book chapters, is participating in several study boards as reviewer of different funding organizations (e.g., HRC New Zealand, Marsden Fund, Raines Grant, Welcome Trust, Swiss National Fund, Academie Louvain, Finish Academy of Science), is ad hoc reviewer of several clinical and scientific journals (such as Nat Neuroscience, Lancet Neurology, Curr Biol, Ann Neurol, Brain and others) and is member of the editorial boards of clinical and neuroscientific journals (e.g., Experimental and Translational Stroke Research, Frontiers in Neuroprosthetics). For his translational research, he received the FARE award of the National Institutes of Health, Bethesda, USA; the Susanne Klein-Vogelbach-Preis zur Erforschung der menschlichen Bewegung, the Dr. Martini Prize of the University of Hamburg and the Prize of the German Society of Neurotraumatology and Clinical Neurorehabilitation.
Within the present talk an overview of current findings regarding (a) changes of interareal interactions and connectivity of network hubs of the sensorimotor network determined by a multimodal systems neuroscience approach including paired-pulse TMS, EEG, structural and functional MR-imaging, (b) modulation of hubs of the sensorimotor network by non-invasive brain stimulation and its effects on motor functions, including executive control and learning, and (c) its underlying mechanisms will be provided. At the end, an outlook on promising future directions such as prediction of recovery, patient stratification for specific treatments, or modelling approaches will be discussed.
Bio: Friedhelm C. Hummel serves as the Vice Director of the Department of Neurology and the Co-Chairman of the University Sleep Laboratory of the University Medical Center Hamburg-Eppendorf, Hamburg. He is the head of the BrainImaging and NeuroStimulation (BINS) Laboratory, and a leading expert in functional regeneration after stroke, mechanisms of healthy aging, interventional neuroscience and neuroplasticity. To this end, he is using a multimodal systems neuroscience research approach in humans, including behavioral tasks focused on executive control and learning, non-invasive brain stimulation, functional and structural imaging and modelling. Since 2013, he is holding a guest professorship at the Favoloro University, Buenos Aires, Argentina. He received grants from various funding organizations, including the German
Research Foundation (DFG), the German Ministry for Research and Education (BMBF) and the Humboldt-Foundation (AvH). So far, he published more than 100 research papers in excellent international peer-reviewed journals and book chapters, is participating in several study boards as reviewer of different funding organizations (e.g., HRC New Zealand, Marsden Fund, Raines Grant, Welcome Trust, Swiss National Fund, Academie Louvain, Finish Academy of Science), is ad hoc reviewer of several clinical and scientific journals (such as Nat Neuroscience, Lancet Neurology, Curr Biol, Ann Neurol, Brain and others) and is member of the editorial boards of clinical and neuroscientific journals (e.g., Experimental and Translational Stroke Research, Frontiers in Neuroprosthetics). For his translational research, he received the FARE award of the National Institutes of Health, Bethesda, USA; the Susanne Klein-Vogelbach-Preis zur Erforschung der menschlichen Bewegung, the Dr. Martini Prize of the University of Hamburg and the Prize of the German Society of Neurotraumatology and Clinical Neurorehabilitation.
Practical information
- Informed public
- Free
Organizer
- Center for Neuroprosthetics