Linking functional genomics and genetic epidemiology association studies to biological responses and clinical phenotypes in leprosy
Event details
| Date | 15.04.2016 |
| Hour | 14:00 › 15:00 |
| Speaker | Milton O. Moraes |
| Location | |
| Category | Miscellaneous |
Large-scale analyses have changed the scenario of infectious diseases studies revealing novel pathways and genes as associated with specific phenotypes of chronic infectious disease such as leprosy and tuberculosis. Then, the ability to test using monocyte in vitro infections with live M. leprae targeting novel main genes are enabling to disclose fully new strategies that mycobacteria developed to subvert protective immune response and drive intracellular environment into a safe niche to replicate and survive. M.leprae infection triggers a combination of signals connecting routes like type-I interferon, lipid and energy metabolism with autophagy. In this context, major genes regulating innate, adaptive and metabolic responses define in one hand pro-mycobacterial or, in the other hand, protective responses in a way that genetic polymorphisms could participate in the definition of the susceptibility status of patient.
Practical information
- Informed public
- Free
Organizer
- Stewart T. Cole
Contact
- Cécile Prébandier