Macrophages within Tumor Microenvironment: Study of Molecular and Cellular Mechanisms Involved in the Anti-Tumor Response
Event details
| Date | 10.02.2020 |
| Hour | 11:00 › 12:00 |
| Speaker | Melissa Prat, Ph.D., UMR-152 / IRD / PharmaDev, Equipe MRN2i, University Hospital (CHU), Rangueil, Toulouse (F) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Macrophages are crucial effectors of innate immune response and exhibit a remarkable plasticity that allows them to adapt to different stimuli present in their microenvironment. During tumor development, mediators secreted by transformed cells « educate » Tumor-Associated Macrophages (TAMs), which acquire properties favorable to tumor growth. It is now widely accepted that TAMs, initially exhibiting an anti-tumor M1 phenotype, differentiate towards an M2 phenotype and promote tumor cell proliferation, angiogenesis, metastases, chemoresistance and immunosuppresion. While this functional M1/M2 dichotomy facilitates the description of TAMs phenotype and their associated functions, it is, however, in many cases an oversimplification of macrophage biology, which is often more complex.
We showed that interleukine-13, a Th2 cytokine known to be involved in macrophage M2 polarization, promotes macrophage cytotoxic activity against several tumor cell lines. Furthermore, we demonstrated in an experimental model of ovarian adenocarcinoma the anti-tumor activity of 15(S)-HETE, a natural ligand of the PPARγ nuclear receptor involved in macrophage M2 polarization. These findings illustrate the complexity of the M1/M2 paradigm in the description of macrophage pro- and anti-tumor functions and support the importance of targeting macrophages in cancer therapy.
Abstract:
Macrophages are crucial effectors of innate immune response and exhibit a remarkable plasticity that allows them to adapt to different stimuli present in their microenvironment. During tumor development, mediators secreted by transformed cells « educate » Tumor-Associated Macrophages (TAMs), which acquire properties favorable to tumor growth. It is now widely accepted that TAMs, initially exhibiting an anti-tumor M1 phenotype, differentiate towards an M2 phenotype and promote tumor cell proliferation, angiogenesis, metastases, chemoresistance and immunosuppresion. While this functional M1/M2 dichotomy facilitates the description of TAMs phenotype and their associated functions, it is, however, in many cases an oversimplification of macrophage biology, which is often more complex.
We showed that interleukine-13, a Th2 cytokine known to be involved in macrophage M2 polarization, promotes macrophage cytotoxic activity against several tumor cell lines. Furthermore, we demonstrated in an experimental model of ovarian adenocarcinoma the anti-tumor activity of 15(S)-HETE, a natural ligand of the PPARγ nuclear receptor involved in macrophage M2 polarization. These findings illustrate the complexity of the M1/M2 paradigm in the description of macrophage pro- and anti-tumor functions and support the importance of targeting macrophages in cancer therapy.
Practical information
- Informed public
- Free
Organizer
- Prof. Kristina Schoonjans (on behalf of the Lausanne Integrative Metabolism and Nutrition Alliance - LIMNA)
Contact
- (*) IMPORTANT NOTICE: All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call at arrival at SV Reception Desk: Administrative Assistant, ext. 39522.