Mammalian Cell Design Using Synthetic Biology
Event details
| Date | 15.04.2019 |
| Hour | 12:15 |
| Speaker | Prof. Wilson Wong, Boston University, Boston, MA (USA) |
| Location | |
| Category | Conferences - Seminars |
WEEKLY BIOENGINEERING COLLOQUIA SERIES
(sandwiches served)
Abstract:
Genetically engineered cells hold great promise for improving therapeutics, diagnostics, animal models, and industrial biotechnological processes. Here I will describe our Universal Chimeric Antigen Receptors for customizable control of T cell responses. This Universal CAR system could improve the safety and efficacy of cellular cancer immunotherapy. I will also discuss our Boolean and Arithmetic through DNA Excision (BLADE) system for designing genetic circuits with multiple inputs and outputs in mammalian cells. BLADE enables execution of sophisticated cellular computation, with applications in cell and tissue engineering. Together, the Universal CAR and BLADE systems highlight an expanding toolset for flexibly controlling mammalian cell functions.
Bio:
Wilson Wong is an Assistant Professor in the Biomedical Engineering Department at Boston University, and a core member of the BU Biological Design Center. The Wong is a design-driven lab is focused on developing synthetic biology tools in mammalian systems for cell-based immunotherapy. He received his B.S. degree in Chemical Engineering from UC Berkeley and a Ph.D. degree in Chemical Engineering from UCLA. He did his postdoctoral work at UCSF. He is the recipient of the NIH Director’s New Innovator, NSF CAREER, ACS Synthetic Biology Young Investigator, BU Ignition, and BU College of Engineering Early Career Research Excellence Award.
Zoom link for attending remotely: https://epfl.zoom.us/j/851169110
(sandwiches served)
Abstract:
Genetically engineered cells hold great promise for improving therapeutics, diagnostics, animal models, and industrial biotechnological processes. Here I will describe our Universal Chimeric Antigen Receptors for customizable control of T cell responses. This Universal CAR system could improve the safety and efficacy of cellular cancer immunotherapy. I will also discuss our Boolean and Arithmetic through DNA Excision (BLADE) system for designing genetic circuits with multiple inputs and outputs in mammalian cells. BLADE enables execution of sophisticated cellular computation, with applications in cell and tissue engineering. Together, the Universal CAR and BLADE systems highlight an expanding toolset for flexibly controlling mammalian cell functions.
Bio:
Wilson Wong is an Assistant Professor in the Biomedical Engineering Department at Boston University, and a core member of the BU Biological Design Center. The Wong is a design-driven lab is focused on developing synthetic biology tools in mammalian systems for cell-based immunotherapy. He received his B.S. degree in Chemical Engineering from UC Berkeley and a Ph.D. degree in Chemical Engineering from UCLA. He did his postdoctoral work at UCSF. He is the recipient of the NIH Director’s New Innovator, NSF CAREER, ACS Synthetic Biology Young Investigator, BU Ignition, and BU College of Engineering Early Career Research Excellence Award.
Zoom link for attending remotely: https://epfl.zoom.us/j/851169110
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson