Mechanism of Iron- and Cobalt-Catalyzed MHAT Hydrofunctionalization of Alkenes
Event details
| Date | 19.05.2025 |
| Hour | 10:30 › 12:00 |
| Speaker | Prof. Patrick Holland, Conkey P. Whitehead Professor of Chemistry at Yale University, USA |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Abstract: A growing and useful class of alkene coupling reactions involves metal-catalyzed hydrogen atom
transfer (MHAT) from a metal-hydride species to an alkene to form a free radical, which undergoes subsequent
bond formation with another substrate. This combination of steps results in a mild net hydrofunctionalization of
the alkene with Markovnikov selectivity, which can produce C–C and C–O bonds in crowded environments. We
have characterized intermediates and key mechanistic steps in cobalt-catalyzed MHAT reactions. These
investigations comprise spectroscopic, mechanistic, and computational studies. Our research has elucidated
some important determinants of catalytic success, and clarified the nature of proposed cobalt(IV) alkyl
intermediates. More generally, we demonstrate a thorough and effective approach to mechanistic studies that
involve paramagnetic organometallic species.
Practical information
- General public
- Free
Organizer
- Prof. Marinella Mazzanti
Contact
- Prof. Marinella Mazzanti