Microfluidics Neuro-Engineering for Neurological Disorder In Vitro Models
Event details
| Date | 22.01.2018 |
| Hour | 16:00 |
| Speaker | Thibault Honegger, Ph.D., CNRS, Grenoble (F) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. Microfluidic systems have been used to develop in vitro microenvironments that mimic part of the complexity when studying in vivo neurological disorders. In this presentation I will highlight our approach to use microfluidic systems to bridge the gap between molecular and network analysis of neural circuits. Using 3D printing technologies and microfluidic neuro-engineering design rules, I will present the translational process to create neural networks of high complexity using computer aided design, to fabricate and then to observe physiologically relevant in vitro neural networks. Combined with proper readout of the network functionality using an electro-optical transducer, such minimalistic environments can provide on-demand neural networks and neurological disorder models for massive drug screening.
Bio:
Thibault Honegger graduated from the Ecole Centrale of Nantes in 2007, and received his MS degree in Biotechnologies from University Joseph Fourrier in 2008 and his PhD degree in electrical engineering at LTM (CNRS/University Grenoble Alpes) in 2011 on 3D electrokinetic handling of cancer cells and particles in lab on chip devices. He was a postdoc fellow at the Voldman lab at MIT in 2012 for two years where he developed and investigated axonal guidance using contact less forces to design neural circuits. He joined CNRS in 2014 as a principal investigator in Grenoble to lead the team microfluidics neuro-engineering. His current research interests include applications and development of microtechnologies and microfluidics in neuroscience, electrical and neural interface technologies and smart implantable devices in silk for neural interfaces. He co-authored 24 peer-reviewed research papers, 5 granted patents and 1 book chapter. He is a member of the editor board of IET NanoBioTechnologies. He founded and is the chairman of the conference Neurofluidics: Neuroscience & Microfluidics. He co-founded Peerus, a web app for scientific paper monitoring, Linkio and Smart Force Technologies.
Abstract:
Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. Microfluidic systems have been used to develop in vitro microenvironments that mimic part of the complexity when studying in vivo neurological disorders. In this presentation I will highlight our approach to use microfluidic systems to bridge the gap between molecular and network analysis of neural circuits. Using 3D printing technologies and microfluidic neuro-engineering design rules, I will present the translational process to create neural networks of high complexity using computer aided design, to fabricate and then to observe physiologically relevant in vitro neural networks. Combined with proper readout of the network functionality using an electro-optical transducer, such minimalistic environments can provide on-demand neural networks and neurological disorder models for massive drug screening.
Bio:
Thibault Honegger graduated from the Ecole Centrale of Nantes in 2007, and received his MS degree in Biotechnologies from University Joseph Fourrier in 2008 and his PhD degree in electrical engineering at LTM (CNRS/University Grenoble Alpes) in 2011 on 3D electrokinetic handling of cancer cells and particles in lab on chip devices. He was a postdoc fellow at the Voldman lab at MIT in 2012 for two years where he developed and investigated axonal guidance using contact less forces to design neural circuits. He joined CNRS in 2014 as a principal investigator in Grenoble to lead the team microfluidics neuro-engineering. His current research interests include applications and development of microtechnologies and microfluidics in neuroscience, electrical and neural interface technologies and smart implantable devices in silk for neural interfaces. He co-authored 24 peer-reviewed research papers, 5 granted patents and 1 book chapter. He is a member of the editor board of IET NanoBioTechnologies. He founded and is the chairman of the conference Neurofluidics: Neuroscience & Microfluidics. He co-founded Peerus, a web app for scientific paper monitoring, Linkio and Smart Force Technologies.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)