Mitochondrial Proteins, Pathways, and Pathogenesis
Event details
| Date | 07.10.2015 |
| Hour | 14:00 › 15:00 |
| Speaker | Prof. David J. Pagliarini, Morgridge Institute for Research, University of Wisconsin, Madison, WI (USA) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Mitochondrial dysfunction is associated with a spectrum of rare inborn errors of metabolism and an increasing number of common diseases, including Parkinson’s, Alzheimer’s, various cancers and type 2 diabetes. However, the nature and cause of this dysfunction is quite often confounding or unclear. Central to this problem is the recent realization that mitochondria are much more complex than once thought and possess hundreds of proteins with no known biochemical functions. Elucidating the biochemical functions of these proteins has become a major bottleneck in understanding basic mitochondrial biology and the pathophysiology of mitochondria-related disorders. The long-term significance of my research program is to widen this biomedical bottleneck by accelerating the functional annotation of key disease-related “orphan” mitochondrial proteins (OMPs), thereby taking an important first step toward rational therapeutic design for many mitochondrial diseases. We do so by first designing large-scale mass spectrometry and computational analyses designed to make initial connections between OMPs and known mitochondrial pathways and processes, and then employing mechanistic and structural approaches to define the functions of select OMPs at biochemical depth.
Bio:
David Pagliarini joined University of Wisconsin-Madison as an assistant professor of biochemistry in 2009, and was appointed associate professor of Biochemistry in 2015. He received his PhD in 2005 in biomedical sciences from the University of California-San Diego and did his postdoctoral training at Harvard Medical School until 2009. He is Director and Nielsen Chair of Metabolism at the Morgridge Institute for Research.
On the web:
Pagliarini Lab
Morgridge Metabolism
Abstract:
Mitochondrial dysfunction is associated with a spectrum of rare inborn errors of metabolism and an increasing number of common diseases, including Parkinson’s, Alzheimer’s, various cancers and type 2 diabetes. However, the nature and cause of this dysfunction is quite often confounding or unclear. Central to this problem is the recent realization that mitochondria are much more complex than once thought and possess hundreds of proteins with no known biochemical functions. Elucidating the biochemical functions of these proteins has become a major bottleneck in understanding basic mitochondrial biology and the pathophysiology of mitochondria-related disorders. The long-term significance of my research program is to widen this biomedical bottleneck by accelerating the functional annotation of key disease-related “orphan” mitochondrial proteins (OMPs), thereby taking an important first step toward rational therapeutic design for many mitochondrial diseases. We do so by first designing large-scale mass spectrometry and computational analyses designed to make initial connections between OMPs and known mitochondrial pathways and processes, and then employing mechanistic and structural approaches to define the functions of select OMPs at biochemical depth.
Bio:
David Pagliarini joined University of Wisconsin-Madison as an assistant professor of biochemistry in 2009, and was appointed associate professor of Biochemistry in 2015. He received his PhD in 2005 in biomedical sciences from the University of California-San Diego and did his postdoctoral training at Harvard Medical School until 2009. He is Director and Nielsen Chair of Metabolism at the Morgridge Institute for Research.
On the web:
Pagliarini Lab
Morgridge Metabolism
Practical information
- Informed public
- Free
Organizer
- Johan Auwerx for the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA)
Contact
- Johan Auwerx
(*) IMPORTANT NOTICE: All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call at arrival at SV Reception Desk: Johan Auwerx 30951/Administrative Assistant: 39522.