Mitochondrial Quality Control
Event details
| Date | 16.02.2017 |
| Hour | 10:30 › 11:30 |
| Speaker | Ziheng CHEN, Group of Apoptosis and Cancer Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
To protect against mitochondrial damage from environment including oxidative stress, cell have developed well-coordinated mechanisms to monitor mitochondrial health. These Mitochondrial Quality Control (MQC) mechanisms include mitochondrial dynamic and mitophagy. Here, we uncovered that the mitochondrial E3 ligase MARCH5 plays a role in regulating hypoxia-induced mitophagy by ubiquitylating and degrading mitophagy receptor FUNDC1, revealing a novel feedback regulatory mechanism to control the protein levels of a mitochondrial receptor to fine-tune MQC. As a part of collaborative research project, we have also revealed an unconventional function of non-degradative ubiquitination of Mfns in promoting mitochondrial fusion.
IMPORTANT:
All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153.
Contact person to call at arrival at SV Reception Desk: Johan Auwerx 30951 /Administrative Assistant: 39522.
To protect against mitochondrial damage from environment including oxidative stress, cell have developed well-coordinated mechanisms to monitor mitochondrial health. These Mitochondrial Quality Control (MQC) mechanisms include mitochondrial dynamic and mitophagy. Here, we uncovered that the mitochondrial E3 ligase MARCH5 plays a role in regulating hypoxia-induced mitophagy by ubiquitylating and degrading mitophagy receptor FUNDC1, revealing a novel feedback regulatory mechanism to control the protein levels of a mitochondrial receptor to fine-tune MQC. As a part of collaborative research project, we have also revealed an unconventional function of non-degradative ubiquitination of Mfns in promoting mitochondrial fusion.
IMPORTANT:
All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153.
Contact person to call at arrival at SV Reception Desk: Johan Auwerx 30951 /Administrative Assistant: 39522.
Links
Practical information
- Informed public
- Free
Organizer
- Prof. Johan Auwerx and Prof. Kristina Schoonjans for the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA)
Contact
- Prof. Johan Auwerx and Prof. Kristina Schoonjans for the LIMNA Alliance