Monitoring and modulating tuberculosis in the transparent zebrafish
Event details
| Date | 24.04.2009 |
| Hour | 15:30 |
| Speaker | Lalita Ramakrishnan |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
The transparent zebrafish has emerged as a powerful model system to study the early events of tuberculosis. This system offers two major advantages: optical clarity and genetic tractability. We use real-time microscopy to visualize the sequential stages of the host-bacterium interaction in experimentally infected animals. We modulate these stages by creating defined mutations in both the host and the pathogen, and we determine how these stages contribute to infection outcomes. Our studies have provided some surprising new insights into the role of the tuberculous granuloma, the hallmark tissue structure of tuberculosis, in the expansion and dissemination of infection within the host.
Links
Practical information
- General public
- Free
Contact
- Prof. John McKinney