mTOR and Lysosomes in Growth Control
Event details
| Date | 29.04.2019 |
| Hour | 12:15 |
| Speaker | Prof. David Sabatini, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA (USA) |
| Location | |
| Category | Conferences - Seminars |
WEEKLY BIOENGINEERING COLLOQUIA SERIES
(sandwiches served)
Abstract:
Our lab is interested in the regulation of growth and metabolism by nutrients and for some time we have focused on the mTOR pathway, particularly the nutrient-sensing network anchored by mTOR Complex 1 (mTORC1). I will discuss our latest work on how mTORC1 senses cytosolic and lysosomal amino acids and the role selective autophagy plays. I will highlight our use of a method we developed to profile the metabolite and protein content of organelles to identify proteins that move on and off lysosomes in response to nutrient conditions. I also may present our use of somatic cell genetics to identify new components of metabolic pathways, particularly in mitochondrial one-carbon metabolism.
Bio:
David M. Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He has been an investigator of the Howard Hughes Medical Institute since 2008 and was elected to the National Academy of Sciences in 2016. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery and study of mTOR, a protein kinase that is an important regulator of cell and organismal growth that is deregulated in cancer, diabetes, as well as the aging process.
Education:
MD/PhD 1997, Johns Hopkins School of Medicine
Research Summary:
We probe the basic mechanisms that regulate growth — the process whereby cells and organisms accumulate mass and increase in size. The pathways that control growth are often hindered in human diseases like diabetes and cancer. Our long-term goals are to identify and characterize these mechanisms, and to understand their roles in normal and diseased mammals.
Zoom link for attending remotely: https://epfl.zoom.us/j/157047466
(sandwiches served)
Abstract:
Our lab is interested in the regulation of growth and metabolism by nutrients and for some time we have focused on the mTOR pathway, particularly the nutrient-sensing network anchored by mTOR Complex 1 (mTORC1). I will discuss our latest work on how mTORC1 senses cytosolic and lysosomal amino acids and the role selective autophagy plays. I will highlight our use of a method we developed to profile the metabolite and protein content of organelles to identify proteins that move on and off lysosomes in response to nutrient conditions. I also may present our use of somatic cell genetics to identify new components of metabolic pathways, particularly in mitochondrial one-carbon metabolism.
Bio:
David M. Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He has been an investigator of the Howard Hughes Medical Institute since 2008 and was elected to the National Academy of Sciences in 2016. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery and study of mTOR, a protein kinase that is an important regulator of cell and organismal growth that is deregulated in cancer, diabetes, as well as the aging process.
Education:
MD/PhD 1997, Johns Hopkins School of Medicine
Research Summary:
We probe the basic mechanisms that regulate growth — the process whereby cells and organisms accumulate mass and increase in size. The pathways that control growth are often hindered in human diseases like diabetes and cancer. Our long-term goals are to identify and characterize these mechanisms, and to understand their roles in normal and diseased mammals.
Zoom link for attending remotely: https://epfl.zoom.us/j/157047466
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson