Neuro-X seminar: Cortex-Wide Opto-Electrophysiological Recordings Using Transparent Inkjet-printed Electrode Arrays
Event details
| Date | 08.05.2023 |
| Hour | 10:30 › 11:30 |
| Speaker | Prof Sarah Swisher |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
Abstract
In parallel with the continued improvement of traditional silicon semiconductor devices, another paradigm of electronics has taken shape: flexible electronic systems. Flexible displays, electronic textiles, bio-inspired sensors, and wearable or implantable medical devices are just a few applications that benefit from large-area form factors and mechanical flexibility, both of which are challenging to achieve with conventional wafer-based electronics. Flexible and printed electronics are ideally suited for sensing applications that require conformable and easily-customizable circuits.
Electrophysiology and optical imaging provide complementary neural sensing capabilities – electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically-defined populations at high spatial resolution. In this talk, I will focus on our recent work developing “eSee-Shells”: chronic multimodal neural interface devices using transparent, inkjet-printed electrocorticography (ECoG) arrays. eSee-Shells combine electrophysiology and optical calcium (Ca2+) imaging for simultaneous large-area, multimodal sensing of neural activity across multiple brain regions. eSee-Shells were implanted on transgenic mice, providing a robust opto-electrophysiological interface for over 100 days. They enable simultaneous mesoscale Ca2+ imaging and ECoG acquisition from multiple brain regions covering 45 mm2 of cortex in anesthetized and awake animals. The accessible cortical surface area in this study is an order of magnitude larger than typical chronic transparent ECoG arrays, where the field of view is often limited to ~2-5 mm2. Finally, I will highlight other applications from our recent work that leverage flexible bioelectronic sensing arrays, as well as our progress combining solution-processed oxide semiconductors with novel photonic processing techniques to produce flexible transistors.
Bio
Sarah L. Swisher is currently an Assistant Professor in the Department of Electrical & Computer Engineering at the University of Minnesota. She received her B.S. in Electrical Engineering from the University of Nebraska-Lincoln, and her M.S. and Ph.D. degrees in Electrical Engineering and Computer Sciences from the University of California, Berkeley. Her current research sits at the intersection of semiconductor device physics, materials science, and bioengineering. She leverages the beneficial properties of flexible electronics to enable new technologies and advancements in biological sensors and medical devices. Her research approach is collaborative and multidisciplinary, with ties to the Center for Neuroengineering (CNE), the Institute for Engineering in Medicine (IEM), and the Translational Center for Resuscitative Trauma Care (TCRTC).
In parallel with the continued improvement of traditional silicon semiconductor devices, another paradigm of electronics has taken shape: flexible electronic systems. Flexible displays, electronic textiles, bio-inspired sensors, and wearable or implantable medical devices are just a few applications that benefit from large-area form factors and mechanical flexibility, both of which are challenging to achieve with conventional wafer-based electronics. Flexible and printed electronics are ideally suited for sensing applications that require conformable and easily-customizable circuits.
Electrophysiology and optical imaging provide complementary neural sensing capabilities – electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically-defined populations at high spatial resolution. In this talk, I will focus on our recent work developing “eSee-Shells”: chronic multimodal neural interface devices using transparent, inkjet-printed electrocorticography (ECoG) arrays. eSee-Shells combine electrophysiology and optical calcium (Ca2+) imaging for simultaneous large-area, multimodal sensing of neural activity across multiple brain regions. eSee-Shells were implanted on transgenic mice, providing a robust opto-electrophysiological interface for over 100 days. They enable simultaneous mesoscale Ca2+ imaging and ECoG acquisition from multiple brain regions covering 45 mm2 of cortex in anesthetized and awake animals. The accessible cortical surface area in this study is an order of magnitude larger than typical chronic transparent ECoG arrays, where the field of view is often limited to ~2-5 mm2. Finally, I will highlight other applications from our recent work that leverage flexible bioelectronic sensing arrays, as well as our progress combining solution-processed oxide semiconductors with novel photonic processing techniques to produce flexible transistors.
Bio
Sarah L. Swisher is currently an Assistant Professor in the Department of Electrical & Computer Engineering at the University of Minnesota. She received her B.S. in Electrical Engineering from the University of Nebraska-Lincoln, and her M.S. and Ph.D. degrees in Electrical Engineering and Computer Sciences from the University of California, Berkeley. Her current research sits at the intersection of semiconductor device physics, materials science, and bioengineering. She leverages the beneficial properties of flexible electronics to enable new technologies and advancements in biological sensors and medical devices. Her research approach is collaborative and multidisciplinary, with ties to the Center for Neuroengineering (CNE), the Institute for Engineering in Medicine (IEM), and the Translational Center for Resuscitative Trauma Care (TCRTC).
Practical information
- Informed public
- Free