Next-Generation Biosensors and Bioimaging Systems Enabled by Nanophotonics
Event details
| Date | 02.09.2019 |
| Hour | 14:00 |
| Speaker | Prof. Hatice Altug, EPFL, Lausanne (CH) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
New healthcare initiatives including point-of-care diagnostics, global health care and precision medicine are demanding breakthrough developments in biosensing and bioanalytical tools. Current biosensors are lacking precision, bulky, and costly, as well as require long detection times, sophisticated infrastructure and trained personnel which limit their application areas. To address these challenges in my laboratory we exploit novel physical phenomena and engineering toolkits such as nanophotonics, nanofabrication and microfluidics. In particular optical nanostructures based on plasmonics and dielectric metasurfaces which can confine light below the fundamental diffraction limit and create extremely intense electromagnetic fields in nanometric volumes are offering tremendous opportunities. In this talk I will present how we exploit nanophotonics and combine it with imaging, biology and chemistry to achieve high performance biosensors with new functionalities. First, I will show ultra-sensitive Mid-IR biosensors based on surface enhanced infrared spectroscopy for chemical specific detection of molecular compounds and real-time monitoring of protein conformations in aqueous environment. Significantly, our recent invention which converts molecular absorption signatures into barcode-like images is opening the doors to empowering nanophotonics with artificial intelligence for detecting materials in new ways. Second, I will describe our effort to develop ultra-compact, portable and low-cost microarrays and use them for disease diagnostics in real-world settings. Finally, I will present powerful label-free optofluidic biosensors that can perform one-of-a-kind measurements on live cells down to the single cell level and provide their prospects in biomedical and clinical applications.
Bio:
Hatice Altug is associate professor at Ecole Ploytechnique Federale de Lausanne (EPFL), in the Institute of Bioenginnering. She is also director of EPFL's Doctoral School in Photonics. She received her Ph.D. in Applied Physics from Stanford University (U.S.A.) in 2007 and a B.S. in Physics from Bilkent University (Turkey) in 2000. Prof. Altug is the recipient of the 2012 Optical Society of America Adolph Lomb Medal and of the 2010 U.S. Presidential Early Career Award for Scientists and Engineers, which is the highest honor bestowed by the United States government on outstanding scientists and engineers in their early career. She received an European Research Council (ERC) Consolidator Grant, an ERC Proof of Concept Grant, a U.S. Office of Naval Research Young Investigator Award, a U.S. National Science Foundation CAREER Award, a Massachusetts Life Science Center New Investigator Award, and an IEEE Photonics Society Young Investigator Award. Altug was the winner of the Inventors’ Challenge competition of Silicon Valley in 2005, and has been named to Popular Science Magazine’s "Brilliant 10" list in 2011.
‘Zoom’ link for attending remotely: click here
Abstract:
New healthcare initiatives including point-of-care diagnostics, global health care and precision medicine are demanding breakthrough developments in biosensing and bioanalytical tools. Current biosensors are lacking precision, bulky, and costly, as well as require long detection times, sophisticated infrastructure and trained personnel which limit their application areas. To address these challenges in my laboratory we exploit novel physical phenomena and engineering toolkits such as nanophotonics, nanofabrication and microfluidics. In particular optical nanostructures based on plasmonics and dielectric metasurfaces which can confine light below the fundamental diffraction limit and create extremely intense electromagnetic fields in nanometric volumes are offering tremendous opportunities. In this talk I will present how we exploit nanophotonics and combine it with imaging, biology and chemistry to achieve high performance biosensors with new functionalities. First, I will show ultra-sensitive Mid-IR biosensors based on surface enhanced infrared spectroscopy for chemical specific detection of molecular compounds and real-time monitoring of protein conformations in aqueous environment. Significantly, our recent invention which converts molecular absorption signatures into barcode-like images is opening the doors to empowering nanophotonics with artificial intelligence for detecting materials in new ways. Second, I will describe our effort to develop ultra-compact, portable and low-cost microarrays and use them for disease diagnostics in real-world settings. Finally, I will present powerful label-free optofluidic biosensors that can perform one-of-a-kind measurements on live cells down to the single cell level and provide their prospects in biomedical and clinical applications.
Bio:
Hatice Altug is associate professor at Ecole Ploytechnique Federale de Lausanne (EPFL), in the Institute of Bioenginnering. She is also director of EPFL's Doctoral School in Photonics. She received her Ph.D. in Applied Physics from Stanford University (U.S.A.) in 2007 and a B.S. in Physics from Bilkent University (Turkey) in 2000. Prof. Altug is the recipient of the 2012 Optical Society of America Adolph Lomb Medal and of the 2010 U.S. Presidential Early Career Award for Scientists and Engineers, which is the highest honor bestowed by the United States government on outstanding scientists and engineers in their early career. She received an European Research Council (ERC) Consolidator Grant, an ERC Proof of Concept Grant, a U.S. Office of Naval Research Young Investigator Award, a U.S. National Science Foundation CAREER Award, a Massachusetts Life Science Center New Investigator Award, and an IEEE Photonics Society Young Investigator Award. Altug was the winner of the Inventors’ Challenge competition of Silicon Valley in 2005, and has been named to Popular Science Magazine’s "Brilliant 10" list in 2011.
‘Zoom’ link for attending remotely: click here
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson