Go to main site

Memento

NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin

Thumbnail

Event details

Date and time 19.06.2019 10:3011:30  
Place and room
Speaker Rebecca George Tharyan, Ph.D, Molecular Genetics of Ageing (Antebi Lab), Max-Planck-Institut for Biology of Ageing, Cologne, Germany
Category Conferences - Seminars
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)

Abstract:
Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms in metazoans remain elusive. To identify mitochondrial regulators, we performed an RNAi screen leveraging the remarkable mitochondrial changes in C. elegans upon recovery from adult reproductive diapause. We discovered NFYB-1, a subunit of the NF-Y transcriptional complex, as a crucial regulator of mitochondrial function. Loss of NFYB-1 leads to reduced mitochondrial gene expression, mitochondrial fragmentation, and abolition of longevity triggered by mitochondrial impairment. Moreover, NFYB-1 deletion disrupts mitochondrial UPRmt factors and mitochondrial-to-cytosolic stress response (MCSR). Multi-omics analysis indicates that NFYB-1 serves as a potent repressor of several ER genes and the ER stress response, as well as lysosomal prosaposin. Downstream of NFYB-1, limiting prosaposin expression alters ceramide and cardiolipin pools, restores mitochondrial fusion, gene expression and longevity. Thus, the NFYB-1/PSAP axis coordinates lysosomal to mitochondrial communication to prolong life.
 

Practical information

  • Informed public
  • Free

Organizer

  • Johan Auwerx on behalf of the Lausanne Integrative Metabolism and Nutrition Alliance - LIMNA

Contact

  • Johan Auwerx

Share

Login