Personal Regulome Navigation
Event details
| Date | 29.11.2016 |
| Hour | 11:00 › 12:00 |
| Speaker | Dr. Howard Chang |
| Location | |
| Category | Conferences - Seminars |
In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code—how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. LncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations. I will describe a new technology based on DNA transposition that reveals the epigenomic profiles of single cells or from clinical biopsies of disease states. Together these insights are enabling the personal navigation of the gene regulatory landscape in health and disease.
Practical information
- General public
- Free